Effect of 1st-trimester loss on restoration of the hypothalamic-pituitary-ovarian axis

Gynecologic and Obstetric Investigation
J C Elkas, D S Cunningham

Abstract

This randomized prospective study was conducted to determine the length of time required for re-establishment of the reproductive axis following a 1st-trimester spontaneous abortion. The spontaneous gonadotropin secretion was significantly depressed during the first menstrual cycle after pregnancy loss, while the estradiol levels had normalized. Provocative testing revealed blunted gonadotropin release in the first menstrual cycle with return to normal during the first menstrual cycle after a spontaneous abortion. Endometrial biopsy specimens were also abnormal during the first menstrual cycle with normal histological characteristics by the second menstrual cycle. Therefore, restoration of the hypothalamic-pituitary- ovarian axis after a 1st-trimester loss is achieved within two menstrual cycles, as determined by return of normal pituitary function.

Citations

Jan 24, 2019·BMJ Open·Cathrine WildenschildEllen M Mikkelsen
May 28, 2010·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Anne Marie Z JukicDonna D Baird
Nov 16, 2020·Frontiers in Neuroendocrinology·Maddalena Sparaco, Simona Bonavita

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