Effect of α2 -Adrenoceptor Stimulation on Functional Parameters of Langendorff-Isolated Rat Heart

Bulletin of Experimental Biology and Medicine
N I ZiyatdinovaT L Zefirov

Abstract

We studied the effect of α2-adrenoreceptor agonist clonidine hydrochloride in concentrations of 10-9-10-6 M on inotropy, chronotropy, and coronary flow in Langendorff-isolated heart of adult rats. It was found that α2-adrenoreceptor agonist changed all studied parameters. Left ventricular myocardium contraction force decreased after application of all tested concentrations, the maximum effect was observed at a concentration of 10-6 M. Stimulation of α2-adrenergic receptors in concentrations of 10-8, 10-7, and 10-6 M produced a two-phase effect (initial increase and a subsequent decrease) on the coronary flow. Clonidine hydrochloride in the maximum concentration (10-6 M) caused a decrease in HR in one group and an increase in the other.

References

Jul 18, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Melanie PhilippLutz Hein
May 24, 2011·Journal of Molecular Graphics & Modelling·Liliana Ostopovici-HalipCristian G Bologa
Jun 25, 2014·Bulletin of Experimental Biology and Medicine·T L ZefirovA L Zefirov
Oct 25, 2016·Journal of Molecular and Cellular Cardiology·Yuri M KokozAlexey E Alekseev

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Citations

Sep 30, 2020·Bulletin of Experimental Biology and Medicine·N I ZiyatdinovaT L Zefirov
Oct 14, 2019·Bulletin of Experimental Biology and Medicine·T L ZefirovA L Zefirov
May 1, 2021·Cells·Anne-Sophie Colombe, Guillaume Pidoux

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