Effect of β2-adrenergic receptor gene (ADRB2) 3' untranslated region polymorphisms on inhaled corticosteroid/long-acting β2-adrenergic agonist response.

Respiratory Research
Helen J AmbroseEugene R Bleecker

Abstract

Evidence suggests that variation in the length of the poly-C repeat in the 3' untranslated region (3'UTR) of the β2-adrenergic receptor gene (ADRB2) may contribute to interindividual variation in β-agonist response. However, methodology in previous studies limited the assessment of the effect of sequence variation in the context of poly-C repeat length. The objectives of this study were to design a novel genotyping method to fully characterize sequence variation in the ADRB2 3'UTR poly-C repeat in asthma patients treated with inhaled corticosteroid and long-acting β2-adrenergic agonist (ICS/LABA) combination therapy, and to analyze the effect of the poly-C repeat polymorphism on clinical response. In 2,250 asthma patients randomized to treatment with budesonide/formoterol or fluticasone/salmeterol in a six-month study (AstraZeneca study code: SD-039-0735), sequence diversity in the ADRB2 poly-C repeat region was determined using a novel sequencing-based genotyping method. The relationship between the poly-C repeat polymorphism and the incidence of severe asthma exacerbations, and changes in pulmonary function and asthma symptoms from baseline to the average during the treatment period, were analyzed. Poly-C repeat genotypes wer...Continue Reading

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Citations

Aug 6, 2013·Current Allergy and Asthma Reports·Stacey M Miller, Victor E Ortega
Aug 8, 2014·Expert Opinion on Drug Metabolism & Toxicology·John J Lima
Jan 7, 2016·Immunity, Inflammation and Disease·Amber DahlinAnn Chen Wu
Dec 29, 2013·The Journal of Allergy and Clinical Immunology·Victor E Ortega, Deborah A Meyers
Jul 12, 2018·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Elise M A SlobAnke H Maitland-van der Zee
Jun 27, 2013·Current Opinion in Allergy and Clinical Immunology·Victor E Ortega, Michael E Wechsler
Aug 4, 2015·Expert Opinion on Drug Metabolism & Toxicology·Kathryn Blake, John Lima

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Methods Mentioned

BETA
genotyping
PCR

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