Effect of 2-butanol and 2-butanone on rat hepatic ultrastructure and drug metabolizing enzyme activity

Journal of Toxicology and Environmental Health
G J TraigerP H Cooke

Abstract

The effect of a single oral dose of 2-butanol (2.2 ml/kg) or 2-butanone (1.87 ml/kg) on hepatic ultrastructure and drug-metabolizing enzyme activity was studied in the rat. A 135-197% increase in acetanilide hydroxylase activity was found in rats sacrificed 12-40 h after dosing with 2-butanol or 2-butanone. A 40-h pretreatment with 2-butanone produced a 155% increase in aminopyrine N-demethylase activity. NADPH-cytochrome c reductase activity and the concentrations of cytochromes P-450 and b5 were largely unaltered 2-40 h after dosing with either agent. Electron microscopic examination of hepatocytes from rats sacrificed 16 h after 2-butanol or 2-butanone revealed a marginal increase in the prevalence of smooth endoplasmic reticulum. However, by 40 h, there was a marked proliferation of the smooth endoplasmic reticulum and reduction in rough endoplasmic reticulum in response to both agents. The most marked potentiation of CCl4 hepatotoxicity occurred when rats were pretreated with 2-butanol or 2-butanone 16 h before CCl4 administration. The coincidental finding of maximal CCl4-induced hepatic injury and elevation of microsomal xenobiotic activity within the same time frame following 2-butanol or 2-butanone supports the hypothes...Continue Reading

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Citations

Dec 23, 1998·Critical Reviews in Toxicology·A Löf, G Johanson
May 7, 2003·International Archives of Occupational and Environmental Health·Ho-Yuan ChangVen-Shing Wang
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ayman S BannagaRamesh P Arasaradnam

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