PMID: 168399Aug 1, 1975

Effect of 2-deoxy-D-glucose on herpesvirus-induced inhibition of cellular DNA synthesis

Journal of Virology
H Ludwig, R Rott

Abstract

In pseudorabies virus-infected cells host DNA synthesis is turned off 4 to 5 h postinfection. In the presence of 0.5 mM 2-deoxy-D-glucose, however, synthesis of both cellular and viral DNA proceeds unimpaired throughout the virus replication cycle. The uptake of radioactive thymidine into mock-infected cells is not altered in the presence of 2-deoxy-D-glucose. Virus-specific protein synthesis and particle formation also proceed in medium containing the deoxy sugar, but the virus particles produced are noninfectious and cell fusion is inhibited.

Citations

Jul 1, 1981·Klinische Wochenschrift·M Doss, F Verspohl
Apr 8, 2016·Future Medicinal Chemistry·Giuseppina Di StefanoLuigi Fiume
Sep 1, 1985·Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Für Klinische Chemie Und Klinische Biochemie·M DossF Verspohl

Related Concepts

Cell Fusion Procedure
Chick Embryo
Deoxy Sugars
Deoxyglucose
DNA, Double-Stranded
DNA Replication
DNA, Viral
Thymic Group Viruses
Kidney
Leucine

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