PMID: 6477598Jan 1, 1984

Effect of 2-mercaptopropionylglycine on lipid peroxidation and drug oxidation in rat liver microsomes

Biochemistry International
J HarataY Ohta


2-Mercaptopropionylglycine, a synthetic thiol, significantly stimulated NADPH-dependent lipid peroxidation by rat liver microsomes, while the thiol inhibited the microsomal aminopyrine N-demethylase activity with an increase in lipid peroxidation. But, a strong inhibition of lipid peroxidation by EDTA could not abolish the inhibition of the N-demethylase activity by the thiol. Besides, the thiol markedly increased not only the Km value for aminopyrine N-demethylase but also the apparent Ks value for aminopyrine binding to the microsomal oxidized cytochrome P-450 by interacting with the cytochrome P-450.

Related Concepts

Amino Acids, Sulfur
Aminopyrine N-Demethylase
Cytochrome P-450 Oxygenase
Lipid Peroxides
Sodium Malondialdehyde
Microsomes, Liver
August Rats

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