Effect of 2 Psoriasis Treatments on Vascular Inflammation and Novel Inflammatory Cardiovascular Biomarkers: A Randomized Placebo-Controlled Trial

Circulation. Cardiovascular Imaging
Nehal N MehtaJoel M Gelfand

Abstract

Psoriasis is a chronic inflammatory disease associated with dyslipidemia, cardiovascular events, and mortality. We aimed to assess and compare the effect of treatment of moderate-to-severe psoriasis with adalimumab or phototherapy on vascular inflammation and cardiovascular biomarkers. Randomized, double-blind, trial of adalimumab, phototherapy, and placebo (1:1:1) for 12 weeks, with crossover to adalimumab for 52 weeks total. Outcomes included vascular inflammation by 18F-fluorodeoxyglucose positron emission tomography/computed tomography and biomarkers of inflammation, insulin resistance, and lipoproteins. Ninety-seven patients were randomized, 92 completed the randomized controlled trial portion; 81 entered the adalimumab extension with 61 completing 52 weeks of adalimumab. There was no difference in change in vascular inflammation at week 12 in the adalimumab group (change compared with placebo, 0.64%; 95% confidence interval, -5.84% to 7.12%) or the phototherapy group (-1.60%; 95% confidence interval, -6.78% to 3.59%) or after 52-week adalimumab treatment (0.02% compared with initiation; 95% confidence interval, -2.85% to 2.90%). Both adalimumab and phototherapy decreased inflammation by serum CRP, interleukin-6. Only adal...Continue Reading

References

Oct 13, 2006·JAMA : the Journal of the American Medical Association·Joel M GelfandAndrea B Troxel
Oct 25, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Gonca G BuralAbass Alavi
Dec 19, 2007·Archives of Dermatology·Joel M GelfandBrian L Strom
Nov 5, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Wengen ChenAbass Alavi
Aug 24, 2013·Journal of Translational Medicine·Nehal N MehtaCarrie Brodmerkel
Oct 19, 2013·JACC. Cardiovascular Imaging·Raphaël DuivenvoordenZahi A Fayad
Nov 26, 2013·JACC. Cardiovascular Imaging·Amparo L FigueroaAhmed Tawakol
Dec 19, 2015·European Journal of Nuclear Medicine and Molecular Imaging·Jan BuceriusUNKNOWN Cardiovascular Committee of the European Association of Nuclear Medicine (EANM)
Sep 23, 2016·Circulation Research·Aditya A JoshiNehal N Mehta
Nov 25, 2016·Nature Reviews. Disease Primers·Jacqueline E GrebAlice B Gottlieb
Mar 5, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Charlotte L HarringtonNehal N Mehta
Mar 14, 2017·The Journal of Investigative Dermatology·Robert BissonnetteJean-Claude Tardif
Aug 29, 2017·The New England Journal of Medicine·Paul M RidkerUNKNOWN CANTOS Trial Group
Oct 29, 2017·Journal of Translational Medicine·Margery A ConnellyNehal N Mehta

❮ Previous
Next ❯

Citations

Nov 21, 2018·International Reviews of Immunology·Antonis A ManolisAntonis S Manolis
Dec 21, 2018·Circulation Research·Alexander V SorokinNehal N Mehta
Jul 19, 2018·Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Società Italiana Di Dermatologia E Sifilografia·Kevin K Wu, April W Armstrong
Mar 2, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·F RenczM Augustin
Oct 22, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·W RungapiromnanUNKNOWN BADBIR Study Group
Jan 10, 2020·The Cochrane Database of Systematic Reviews·Emilie SbidianLaurence Le Cleach
Jun 22, 2019·The British Journal of Dermatology·N J Korman
Sep 10, 2019·The British Journal of Dermatology·P Gisondi
Sep 19, 2019·The Clinical Biochemist. Reviews·Shelley GormanRobyn M Lucas
Sep 12, 2020·Journal of the American Heart Association·Susanne KarbachKarsten Keller
Mar 7, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Michael S GarshickJeffrey S Berger
Mar 13, 2020·Frontiers in Pharmacology·Paolo GisondiCristina Albanesi
Sep 23, 2020·Journal of Clinical Medicine·Johannes WildKarsten Keller
Jul 10, 2019·The Journal of Dermatological Treatment·Andreas PinterMaximilian Reinhardt
Feb 15, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Michael S GarshickJeffrey S Berger
Nov 10, 2020·Journal of Psoriasis and Psoriatic Arthritis·Alexander V SorokinNehal N Mehta
Jan 26, 2021·Clinical, Cosmetic and Investigational Dermatology·Jeremy G LightSteven R Feldman
Apr 3, 2021·Journal of the American College of Cardiology·Michael S GarshickJeffrey S Berger
Apr 17, 2021·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Athina TrakakiGunther Marsche
Apr 20, 2021·The Cochrane Database of Systematic Reviews·Emilie SbidianLaurence Le Cleach
Apr 24, 2021·The Journal of Investigative Dermatology·Di YanWilson Liao
Jan 27, 2019·The Journal of Allergy and Clinical Immunology·Aaron M Drucker, Paula J Harvey
May 28, 2021·European Cardiology·Ahmed ZwainHussein Taqi
Jul 7, 2021·Journal of Cardiovascular Computed Tomography·Nidhi H PatelNehal N Mehta
Aug 11, 2021·Lipids in Health and Disease·Bai RuiyangFu Siqi
Sep 2, 2021·Current Atherosclerosis Reports·Brittany WeberMichael S Garshick

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Related Papers

Annales de dermatologie et de vénéréologie
F Aubin, Groupe de recherche sur le psoriasis de la Société française de dermatologie
Nature Reviews. Drug Discovery
Bornadata Bain, Melanie Brazil
Annales de dermatologie et de vénéréologie
F Aubin, H Barthelemy
© 2022 Meta ULC. All rights reserved