PMID: 11905956Mar 22, 2002Paper

Effect of 24-h food deprivation on lipoprotein composition and oleoyl-estrone content of lean and obese Zucker rats

European Journal of Nutrition
J Peinado-OnsurbeM Alemany

Abstract

Food deprivation induces the mobilization of fat reserves and, consequently, the transport of lipids in plasma. Zucker obese rats are grossly hyperlipidemic and do not use lipids as an efficient energy substrate. They also have lower circulating levels of acyl-estrone than expected because of their large fat stores. To measure the effect of 24 h food deprivation on hyperlipidemia and acyl-estrone distribution in plasma in Zucker obese rats. The plasma lipoprotein distribution and composition of Zucker lean (Fa/?) and obese (fa/fa) rats was determined after 24 hours of food deprivation. Lipid classes: phospholipid, free and esterified cholesterol and triacylglycerols, and protein and total (mainly acyl-) estrone were also measured in total plasma and lipoprotein fractions. Food-deprived rats showed lower triacylglycerol levels than fed rats, but obese rats maintained high lipid levels, mainly in the VLDL fraction. The ratio of total plasma free-to-esterified cholesterol was lower in fed lean rats (0.29) than in the obese (0.61); the situation improved slightly after 24-h starvation, since the corresponding ratios were 0.30 and 0.41. Acyl estrone levels changed little with 24-h food deprivation. The chylomicra + VLDL total estron...Continue Reading

Citations

Apr 22, 2010·Journal of Lipid Research·Thomas GautierUwe J F Tietge
Feb 3, 2011·Medicinal Research Reviews·Xavier RemesarMarià Alemany
Oct 15, 2008·Journal of Pediatric Gastroenterology and Nutrition·John PohlRonald Macfarlane
Jun 17, 2021·American Journal of Physiology. Gastrointestinal and Liver Physiology·Belén Rivero-GutiérrezOlga Martínez-Augustin
Feb 12, 2011·The Journal of Steroid Biochemistry and Molecular Biology·Ruth VilàMarià Alemany

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