Effect of 24-hour storage at 25 degrees C on the in vitro storage characteristics of CPDA-1 packed red cells

Transfusion
J P RuddellJ R Hess

Abstract

Packed red cells (RBCs) warmed above 10 degrees C are generally discarded. Few data exist on the degree of accelerated metabolism and increased hemolysis of packed RBCs allowed to warm. Twenty-four CPDA-1 packed RBC units were combined in 3-unit pools and subdivided into 2 test units and a control unit. One test unit from each pool was warmed to 25 degrees C for 24 hours on Day 6 and the other test unit was warmed on Day 20; control units were maintained at 1 to 6 degrees C. RBC and supernatant chemistries and RBC morphology were measured weekly (Days 0, 7, 14, 21, and 28) and on the day before warming (Days 6 and 20). Warming CPDA-1 packed RBCs accelerated the catabolism of glucose 10-fold and produced concentrations of glucose, lactate, and ATP after 25 days of storage that were equivalent to those in unwarmed units at 35 days. Supernatant sodium and potassium concentrations were corrected partially with warming. RBC morphology transiently normalized with warming and without increased hemolysis; no bacteria growth was detected. One day of 25 degrees C storage of CPDA-1 packed RBCs accelerates essential metabolite break-down equivalent to 10 days of storage at 1 to 6 degrees C. It does not appear to matter whether the packed R...Continue Reading

Citations

Apr 6, 2004·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Jean-François HardyUNKNOWN Groupe d'intérêt en Hémostase Périopératoire
Jun 13, 2006·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Jean-François HardyUNKNOWN Members of the Groupe d'Intérêt en Hémostase Périopératoire
May 18, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Vedat Schwenger, Christian Morath
Nov 17, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Markus WahrmannGeorg A Böhmig
Feb 1, 1997·Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis·G A Matthes
Apr 25, 2014·Thrombosis Research·Maria M AlemanAlisa S Wolberg
Nov 17, 2009·Journal of Proteomics·John R Hess
Oct 26, 2007·Transfusion·J D HughesJ R Hess
May 12, 2010·Transfusion Medicine·S ThomasR Cardigan
Feb 12, 2011·Transfusion·Stephen ThomasRebecca Cardigan
Dec 3, 2014·Anaesthesia·D Orlov, K Karkouti
Jan 23, 2014·Vox Sanguinis·J R Hess
Aug 10, 2020·Anesthesia and Analgesia·Zacherie R ConoverDebnath Chatterjee
Oct 19, 2020·Australian Critical Care : Official Journal of the Confederation of Australian Critical Care Nurses·Maria Paula Oliveira PiresMavilde Luz Gonçalves Pedreira

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