PMID: 1195563Nov 1, 1975Paper

Effect of 25-hydroxycholecalciferol on calcium absorption in chronic renal disease

Kidney International
W E RutherfordE Slatopolsky

Abstract

Calcium absorption was measured in eight uremic patients before and after eight days of treatment with 100 or 500 mug of 25-hydroxycholecalciferol (25(OH)D3) per day. Fractional calcium absorption was estimated by administering 47Ca i.v. and orally on separate days and counting forearm radioactivity four hours later. Calcium absorption in four patients with residual renal function rose from 16.3 +/- 2.5 to 40.8 +/- 5.5% after treatment. In order to determine if the increased calcium absorption was mediated by an increase in the production of 1,25-dihydroxycholecalciferol (1,25(OH)2D3) by virtue of increased substrate delivery to the 25-hydroxycholecalciferol-1-hydroxylase system present in the residual renal tissue, identical studies were performed in four anephric patients. Calcium absorption in these patients averaged 15.7 +/- 2.2% during the control period and rose to 46.0 +/- 11.1% after treatment. Increments in serum calcium after treatment were similar in both groups of patients; the mean concentration rose from 9.6 +/- 0.3 to 11.0 +/- 0.6 mg/100 ml. The results indicate that 25(OH)D3 can improve calcium absorption in the absence of renal tissue suggesting that its conversion to 1,25(OH)2D3 may not be necessary for its ef...Continue Reading

References

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Citations

Apr 15, 1977·Clinica Chimica Acta; International Journal of Clinical Chemistry·D B CookG Shannan
Nov 10, 1977·The New England Journal of Medicine·M R Haussler, T A McCain
Nov 17, 1977·The New England Journal of Medicine·W PerryP G Walker
Jan 5, 1978·The New England Journal of Medicine·J FreitagE Slatopolsky
Feb 5, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Pierre DelanayeEtienne Cavalier
Oct 1, 1980·Kidney International·S G MassryH H Malluche
Feb 1, 1981·Kidney International·D A GoldsteinS G Massry
Dec 1, 2009·The Journal of Steroid Biochemistry and Molecular Biology·Yan-Ru LouPentti Tuohimaa
Apr 1, 1977·The American Journal of Medicine·K H Stenzel
Mar 16, 2012·The Journal of Clinical Endocrinology and Metabolism·Karin AmreinHarald Dobnig
May 2, 2013·The Journal of Clinical Endocrinology and Metabolism·Marie MetzgerUNKNOWN NephroTest Study Group
Nov 12, 2010·The American Journal of Clinical Nutrition·Robert P Heaney

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