Feb 1, 1977

Effect of 3-acetylpyridine on the functional activity of the adrenal cortex

Biulleten' eksperimental'noĭ biologii i meditsiny
Iu A TarasovV V Vinogradov

Abstract

A reduction of blood corticosteroid content was observed in rats blood after the administration of 3-acetylpyridine. The rats given ACTH after 3-acetylpyridine showed a lesser elevation of corticosteroids in the blood and adrenal gland tissue than the intact animals; 3-acetylpyridine diminished the activity of dehydrogenase glucose-6-phosphate in the adrenal glands. The authors suggested that the action of acetylpyridine was realized at the adrenal gland level and consisted in inhibition of the NADP-H2 generation in the dehydrogenase systems.

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Mentioned in this Paper

Adrenal Gland Tissue
Pyridines
Depression, Chemical
POMC wt Allele
Corticosteroid [EPC]
Corticosteroids, topical for treatment of hemorrhoids and anal fissures
3-acetylpyridine
Glucosephosphate Dehydrogenase
Adrenal Cortex Hormones
Adrenal Glands

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