Effect of 3 excimer laser ablation frequencies (200 Hz, 500 Hz, 1000 Hz) on the cornea using a 1000 Hz scanning-spot excimer laser

Journal of Cataract and Refractive Surgery
Ramin KhoramniaChristoph Winkler von Mohrenfels

Abstract

To evaluate the possible side effects on human and porcine cadaver eyes induced by excimer laser ablation with 3 ablation frequencies. Augenklinik, Klinikum rechts der Isar, Technische Universitaet Muenchen, Munich, Germany. Central epithelial abrasion was performed on porcine and human donor eyes. Next, the porcine eyes were photoablated (-9.00 diopters) at 1 of 3 frequencies (200 Hz, 500 Hz, or 1000 Hz) using a prototype 1000 Hz excimer laser. The human eyes were ablated at 1000 Hz. The surface of the stroma as well as the structure and ultrastructure of the corneal cells and stroma were examined using light microscopy, transmission electron microscopy, and scanning electron microscopy (SEM). Special attention was given to the detection of potential thermal damage and the evaluation of corneal smoothness. Histopathologic examination showed very low to almost no differences between the 3 repetition rates. In all cases, SEM showed an equally smooth surface. The structural and ultrastructural evaluation of corneas treated with ablation frequencies of 200 Hz, 500 Hz, and 1000 Hz showed no specific side effects associated with the high repetition rates. The ablation quality was comparable in the 3 frequency groups. However, the tr...Continue Reading

References

Jan 1, 1988·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·T BendeJ Wollensak
Jan 1, 1986·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·T Seiler, J Wollensak
Nov 1, 1973·Beiträge Zur Pathologie·H PuchtlerL S Valentine
Dec 1, 1983·American Journal of Ophthalmology·S L TrokelB Braren
Jun 20, 2001·Cornea·C Maldonado-CodinaN Efron
Apr 26, 2002·Journal of Cataract and Refractive Surgery·David Huang, Muhammad Arif
Jul 26, 2005·Journal of Cataract and Refractive Surgery·David P S O'BrartJohn Marshall
May 3, 2006·Lancet·Tohru SakimotoDimitri T Azar
May 16, 2006·Journal of Cataract and Refractive Surgery·Tobias KollerTheo Seiler
Jun 27, 2006·Investigative Ophthalmology & Visual Science·Mike P HolzerGerd U Auffarth
Apr 4, 2008·Investigative Ophthalmology & Visual Science·Nikolaos S TsiklisIoannis G Pallikaris
May 24, 2008·Journal of Cataract and Refractive Surgery·George D KymionisIoannis G Pallikaris
Aug 30, 2008·Lasers in Surgery and Medicine·Leia M ShanyfeltDavid W Hahn

❮ Previous
Next ❯

Citations

Nov 26, 2015·Eye and Vision·Samuel Arba MosqueraColm McAlinden
Oct 10, 2020·Journal of Refractive Surgery·Suphi TaneriH Burkhard Dick
Jun 10, 2011·Current Opinion in Ophthalmology

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.