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Effect of 3-methylcholanthrene treatment on phenacetin O-dealkylation in several inbred mouse strains

Drug Metabolism and Disposition : the Biological Fate of Chemicals

Jan 1, 1975

P J PoppersAllan H Conney

PMID: 1225

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Abstract

An increase in the metabolism of phenacetin to N-acetyl-p-aminophenol is correlated with benzo[a]pyrene hydroxylase induction by 3-methylcholanthrene among several inbred mouse strains. While the magnitude of induction of phenacetin O-dealkylation is considerably less than that of benzo...read more

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  • Effect of 3-methylcholanthrene treatment on phenacetin O-dealkylation in several inbred mouse strains

    Drug Metabolism and Disposition : the Biological Fate of Chemicals

    Jan 1, 1975

    P J PoppersAllan H Conney

    PMID: 1225

    DOI:

    Abstract

    An increase in the metabolism of phenacetin to N-acetyl-p-aminophenol is correlated with benzo[a]pyrene hydroxylase induction by 3-methylcholanthrene among several inbred mouse strains. While the magnitude of induction of phenacetin O-dealkylation is considerably less than that of benzo...read more

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