Nov 1, 1975

Effect of 3-methylcholanthrene treatment on phenacetin O-dealkylation in several inbred mouse strains

Drug Metabolism and Disposition : the Biological Fate of Chemicals
P J PoppersA H Conney

Abstract

An increase in the metabolism of phenacetin to N-acetyl-p-aminophenol is correlated with benzo[a]pyrene hydroxylase induction by 3-methylcholanthrene among several inbred mouse strains. While the magnitude of induction of phenacetin O-dealkylation is considerably less than that of benzo[a]pyrene hydroxylation, the data indicate that in mice, the metabolism of these two substrates is under similar regulatory control.

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Mentioned in this Paper

Metabolic Process, Cellular
20-Methylcholanthrene
Acetaminophen
Methylcholanthrene
Benzopyrene Hydroxylase
Mice, Inbred DBA
Dealkylation
Mice, Inbred C3H
Benzo(a)pyrene
Metabolic Pathway

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