Effect of 30 per cent maternal nutrient restriction from 0.16 to 0.5 gestation on fetal baboon kidney gene expression

The Journal of Physiology
Laura A CoxP W Nathanielsz

Abstract

Previous studies in rodents and sheep show that maternal nutrient restriction during pregnancy alters fetal renal development. To date, no studies using fetal baboon RNA with human Affymetrix gene chips have been published. In the present study we have (1) evaluated the specificity of the Affymetrix human gene array 'Laboratory on a Chip' system for use with fetal baboon mRNA and (2) investigated the effects of moderate maternal global nutrient restriction (NR; 70% of ad libitum animals) from early (30 days gestation (dG)) to mid-gestation (90 dG; term = 184 dG) on the fetal baboon kidney. Morphometric and blood measurements were made on 12 non-pregnant baboons before they were bred. All baboons were fed ad libitum until 30 days pregnant, at which time six control baboons continued to feed ad libitum (control - C) while six received 70% of the C diet on a weight adjusted basis. Fetal kidneys were collected following caesarean section at 90 dG, with samples flash frozen and fixed for histological assessment. Fetal hip circumference was decreased in the NR group (68 +/- 2 versus 75 +/- 2 mm), while fetal body weight and all other measurements of fetal size were not different between C and NR at 90 dG. Maternal body weight was dec...Continue Reading

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Citations

Nov 1, 2013·ILAR Journal·Laura A CoxJohn L VandeBerg
Jun 10, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jaehyek ChoiPeter W Nathanielsz
Oct 31, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jeffrey S Gilbert, Mark J Nijland
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Mar 14, 2013·The Journal of Endocrinology·Cun LiPeter W Nathanielsz
Sep 29, 2015·Journal of Medical Primatology·Hillary F HuberPeter W Nathanielsz
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Apr 22, 2015·Journal of Medical Primatology·Hillary F HuberPeter W Nathanielsz
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Jul 27, 2017·Journal of Medical Primatology·Cun LiPeter W Nathanielsz
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Oct 1, 2019·Journal of Developmental Origins of Health and Disease·Hillary F HuberPeter W Nathanielsz
Oct 7, 2017·ILAR Journal·Laura A CoxJohn L VandeBerg
Mar 5, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Melissa A KirigitiPaul Kievit
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Apr 1, 2018·Journal of Medical Primatology·Kimberly D Spradling-ReevesLaura A Cox
May 12, 2018·Journal of Medical Primatology·Lydia E O LightPeter W Nathanielsz
Apr 27, 2017·Frontiers in Aging Neuroscience·Katja FrankePeter W Nathanielsz
Dec 23, 2020·Journal of Developmental Origins of Health and Disease·G D ClarkeP W Nathanielsz
Dec 4, 2020·Molecular and Cellular Pediatrics·Eva NüskenKai-Dietrich Nüsken

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