PMID: 11329490May 1, 2001Paper

Effect of 4-methylpyrazole on endogenous plasma ethanol and methanol levels in humans

Alcoholism, Clinical and Experimental Research
T Sarkola, C J Eriksson

Abstract

Endogenous methanol and ethanol levels are found in human blood. It is assumed that these compounds are derived mainly from microflora in the gastrointestinal tract and that the small amounts formed are consequently eliminated, mainly in the liver, by the alcohol dehydrogenase (ADH) pathway. The objective of the present study was to investigate the effect of 4-methylpyrazole (4-MP), a specific ADH inhibitor, on endogenous plasma methanol and ethanol levels in healthy women and men. A double-blind placebo-controlled interventional study was carried out. A significant elevation in plasma endogenous ethanol and methanol levels was observed after intake of 4-MP (10-15 mg/kg p.o.). For methanol levels, a linear increase from 20 +/- 14 micromol/l before intake to 39 +/- 22 micromol/l at 420 min from intake of 4-MP (levels 20 +/- 14 micromol/l and 14 +/- 9 micromol/l during the corresponding placebo time points) was found. For ethanol, concentrations increased from levels below detection limit (i.e., < 5 micromol/l, determined by headspace gas chromatography) before intake to 30 +/- 20 micromol/l at 195 min from intake of 4-MP. A small increase in ethanol levels, to 13 +/- 8 micromol/l, but not in methanol levels, was observed after t...Continue Reading

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Citations

Feb 15, 2013·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·J R HutsonB M Kapur
Aug 4, 2004·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Ana Maria PáezLawrence Quang
Mar 4, 2014·PloS One·Tatiana V KomarovaYuri L Dorokhov
Jul 18, 2014·PloS One·Anastasia V ShindyapinaYuri L Dorokhov
Jun 5, 2015·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Lisa A SpacekSteven F Solga
Nov 24, 2007·Alcoholism, Clinical and Experimental Research·Bhushan M KapurPeter L Carlen
Oct 12, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Lixin ZhuSteven R Gill
Mar 22, 2012·Alcoholism, Clinical and Experimental Research·Irene ZelnerGideon Koren
Feb 20, 2014·Journal of Gastroenterology and Hepatology·Amit GoelRakesh Aggarwal
Apr 20, 2004·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Ewa CzechJoanna Nowicka
Jun 20, 2015·BioMed Research International·E LauP Freitas
Apr 3, 2015·Physiological Reviews·Yuri L DorokhovTatiana V Komarova

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