Effect of 4-Phenylbutyric Acid and Tauroursodeoxycholic Acid on Magnesium and Calcium Metabolism in Streptozocin-Induced Type 1 Diabetic Mice

Biological Trace Element Research
Qi ZhouJiancheng Xu

Abstract

Recent evidence has identified a role of micronutrients, such as magnesium (Mg2+) and calcium (Ca2+), in glycemic control. 4-Phenylbutyric acid (PBA) and tauroursodeoxycholic acid (TUDCA) are molecular chaperones that can improve protein folding and alleviate endoplasmic reticulum (ER) stress. Increasingly, research is focusing on the association between molecular chaperones and micronutrients. This study established and characterized a mouse model of type 1 diabetes (T1D) and investigated the effect of PBA and TUDCA on Mg2+ and Ca2+ metabolism in these mice. T1D was established in Friend virus B-type mice using multiple low doses of streptozotocin. Mice were administered chaperones. Mg2+and Ca2+ levels in tissues and serum were detected using acid digestion and ICP-MS. At 2 weeks and 2 months after chaperone administration was initiated, Mg2+ levels in the heart, liver, kidney, and serum and Ca2+ levels in spleen and serum of T1D mice were significantly decreased compared with controls; Ca2+ levels in the kidney and muscle of T1D mice were significantly increased; Mg2+ and Ca2+ levels in the heart, liver, kidney, muscle, spleen, and serum were positively correlated in control and T1D mice; and PBA restored renal Mg2+ levels to...Continue Reading

References

Nov 24, 2007·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Tadashi Ikegami, Yasushi Matsuzaki
Nov 3, 2010·Journal of Molecular and Cellular Cardiology·Asli F Ceylan-IsikJun Ren
Dec 7, 2011·Experimental Diabetes Research·Jiancheng XuLu Cai
May 15, 2015·Diabetes, Obesity & Metabolism·Frank C Mooren
Jul 15, 2015·International Journal of Occupational Medicine and Environmental Health·Wah-Yun LowAlexander Lourdes Samy
Jul 21, 2015·Cell Metabolism·Ana Paula Arruda, Gökhan S Hotamisligil
Sep 1, 2015·World Journal of Diabetes·Mario Barbagallo, Ligia J Dominguez
Jan 24, 2018·American Journal of Physiology. Renal Physiology·Dibyendu K PandaAndrew C Karaplis
Apr 19, 2018·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Xi ChenGuoqing Zhao
Jun 20, 2018·Lancet·Linda A DiMeglioRichard A Oram

❮ Previous
Next ❯

Methods Mentioned

BETA
protein folding
Assay

Related Concepts

Related Feeds

ATP Synthases

ATP synthases are enzymes located in the inner mitochondrial membrane that catalyze the synthesis of ATP during cellular respiration. Discover the latest research on ATP synthases here.

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.