PMID: 12787909Jun 6, 2003Paper

Effect of 5-aminosalicylic acid on radiation-induced micronuclei in mouse bone marrow

Mutation Research
M Sudheer KumarP Uma Devi

Abstract

5-Aminosalicylic acid (5ASA), a prescribed drug for ulcerative colitis, is a potent scavenger of oxygen-derived free radicals. The present study was undertaken to ascertain its ability to protect against radiation-induced damage. The drug dose-dependent effect, optimum time of drug administration and radiation dose-dependent effect (0-4 Gy) on in vivo radiation protection against micronuclei induction in polychromatic erythrocytes (PCE) and normochromatic erythrocytes (NCE) were studied in the bone marrow of mice. Intraperitoneal injection of 10-125 mg/kg of the drug 30 min before whole body irradiation with 3 Gy produced a significant reduction in the frequency of micronucleated erythrocytes at 24 h after exposure. The optimum dose for protection without drug toxicity was 25 mg/kg body weight. Injection of 25 mg/kg of the drug 60 or 30 min before or within 15 min after 3 Gy whole body gamma-irradiation resulted in a significant decrease in the radiation-induced PCE and NCE with micronuclei (MPCE and MNCE) and an increase in the ratio of PCE to NCE (P/N), at 24 h post-irradiation. Maximum effect was seen when the drug was administered 30 min before irradiation. Therefore, to study the radiation dose-response, mice were pre-trea...Continue Reading

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Citations

Jun 5, 2008·Proceedings of the National Academy of Sciences of the United States of America·Bo-Jian ZhengKwok-Yung Yuen
Mar 21, 2008·Mutagenesis·Sudheer K MantenaP Uma Devi
Sep 3, 2014·Biomedical Journal·Shrikant L PatilK P Rajashekhar
Jan 26, 2016·Medicinal Research Reviews·Mohammad Zahid KamranVibha Tandon
Dec 25, 2007·Mutation Research·S K MantenaT Mukherjee
Jan 9, 2007·European Journal of Pharmacology·Vipan Kumar PariharChamallamudi Mallikajuna Rao
Sep 1, 2004·Current Therapeutic Research, Clinical and Experimental·Neşe Kiremit-KorkutHatice Bilge
Nov 23, 2006·Chemico-biological Interactions·K R PrabhakarM K Unnikrishnan
Oct 1, 2009·Environmental and Molecular Mutagenesis·Libo LiuShuzheng Liu
May 3, 2011·Free Radical Biology & Medicine·Nazir M KhanKrishna B Sainis
Sep 22, 2011·Mutation Research·Archana P RB S Satish Rao
Sep 21, 2016·International Journal of Molecular Sciences·Laura A BannisterDmitry Y Klokov
Oct 26, 2005·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Tatiana IvanovaJie-Young Song
Jul 9, 2005·Mutation Research·Amardeep JaiswalM K Unnikrishnan
Dec 15, 2010·Journal of Polymer Science. Part A, Polymer Chemistry·Youngmi Kim, Kathryn E Uhrich
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