PMID: 5259768Jul 1, 1969Paper

Effect of 5-bromodeoxyuridine on expression of cultured chondrocytes grown in vitro

Proceedings of the National Academy of Sciences of the United States of America
H S HolthausenH Holtzer

Abstract

Exposure of cultured cartilage cells to 5-bromodeoxyuridine results in a rapid loss of the ability to synthesize the chondroitin 4-sulfate-protein complex characteristic of the extracellular matrix of differentiated cartilage. UDP-glucose dehydrogenase, UDP-N-acetyl hexosamine 4-epimerase and the enzyme system responsible for catalyzing 3'-phosphoadenosine-5'-phosphosulfate synthesis all progressively decline in activity, while several other cellular processes seem unaffected. However, there are marked morphological changes which may be associated with plasma membrane components or the synthesis of the protein-polysaccharide complex.

References

Aug 1, 1965·Proceedings of the National Academy of Sciences of the United States of America·E Marler, E A Davidson
Dec 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·M GoulianR L Sinsheimer
Apr 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·J Abbott, H Holtzer
Nov 1, 1965·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·K Okazaki, H Holtzer
Sep 1, 1968·The Journal of Cell Biology·H IshikawaH Holtzer
Jan 27, 1969·Biochemical and Biophysical Research Communications·S ChackoH Holtzer
Feb 1, 1960·Archives of Biochemistry and Biophysics·E J SMITH, R W WHEAT
Feb 1, 1965·Proceedings of the National Academy of Sciences of the United States of America·R G HAM

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Citations

Nov 1, 1975·Quarterly Reviews of Biophysics·H HoltzerM Okayama
May 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·S Silagi, S A Bruce
Sep 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·S Y Lin, A D Riggs
Aug 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·D Levitt, A Dorfman
Mar 1, 1971·The Journal of Cell Biology·Y Miura, F H Wilt
Jul 1, 1972·The Journal of Cell Biology·H K HagopianV M Ingram
Jan 27, 1975·Annals of the New York Academy of Sciences·E BorenfreundA Bendich
Jun 14, 1976·Journal of Molecular Biology·J N Lapeyre, I Bekhor
Dec 17, 1971·Biochemical and Biophysical Research Communications·S Y Lin, A D Riggs
Feb 1, 1971·Journal of Theoretical Biology·R Tsanev, B Sendov
Mar 16, 1976·Differentiation; Research in Biological Diversity·R L Seecof, S A Dewhurst
Oct 1, 1974·European Journal of Biochemistry·P Stambrook, R Williamson
Jul 1, 1990·Teratology·J G BanniganA Morris
Jun 1, 1973·Journal of Virology·S St Jeor, F Rapp
Sep 2, 1975·Differentiation; Research in Biological Diversity·C B Wigley

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