Effect of 5-HT1A receptor activation on hypothalamic glucose

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
J-P VoigtH Fink

Abstract

The somatodendritic 5-HT1A agonist 8-OH-DPAT reduces serotonergic activity and stimulates feeding in freely feeding rats. Interactions between circulating glucose and 5-HT1A receptor expression related to feeding have been described. The aim of the present microdialysis study was to (1) describe the relation between feeding and glucose in the LH, (2) to investigate if peripherally administered 8-OH-DPAT itself has an effect on extracellular glucose in the lateral hypothalamus (LH) of conscious rats. Baseline glucose concentrations were significantly different in microdialysis samples obtained from food deprived rats compared to freely feeding rats. After re-feeding, a significant rise in glucose levels by 45% was observed in the formerly food deprived rats. In freely feeding rats, 8-OH-DPAT (0.3 mg/kg, i.p.) reduced glucose level in the LH significantly. The effect of 8-OH-DPAT on brain glucose was antagonized by pre-treatment with the 5-HT1A antagonist WAY 100635 (3 mg/kg i.p.) which had no effect on its own. The data indicate, therefore, that the effect of 8-OH-DPAT on hypothalamic glucose is mediated by 5-HT1A receptors. In contrast, the same dose of 8-OH-DPAT proven effective in the brain had no effect on peripheral glucose...Continue Reading

Citations

Dec 29, 2013·Lipids in Health and Disease·Isy F de SousaEliane B Ribeiro
May 10, 2011·Physiology & Behavior·Luis HernándezPedro Rada
Feb 24, 2007·Progress in Neurobiology·Christian P MüllerMaria A De Souza Silva
Sep 29, 2006·The European Journal of Neuroscience·C H MayerJ-P Voigt
Dec 3, 2014·European Journal of Pharmacology·Donald R Gehlert, Janice Shaw
Sep 15, 2014·Behavioural Brain Research·Jörg-Peter Voigt, Heidrun Fink

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