PMID: 9430788Feb 7, 1998Paper

Effect of 5-hydroxytryptamine on gastrointestinal motility in conscious guinea-pigs

Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society
M NakajimaZ Itoh

Abstract

Many studies have suggested that 5-hydroxytryptamine (5HT, serotonin) plays an important role in the control of gastrointestinal motility. However, most of these studies have been carried out on guinea-pig ileum in vitro. Therefore, we investigated the mechanisms of action of 5HT on gastrointestinal motility in conscious guinea-pigs. In order to investigate the effects of 5HT on gastrointestinal motility, extraluminal force transducers were sutured onto the serosal surfaces of the gastric antrum, duodenum and ileum and 5HT was infused intravenously. One of three types of 5HT antagonist or atropine was given before a 5HT infusion of 3.0 micrograms kg-1 min-1 was started. Regular cyclic patterns were observed from the gastric antrum to the ileum in both the fasted and fed states. 5HT increased the contraction amplitudes at all sites. 5HT-induced contractions in the gastric antrum and duodenum were significantly inhibited by methysergide, ondansetron and atropine, but not by ketanserin. In the ileum, only atropine inhibited 5HT-induced contractions. These results suggest that 5HT increases the gastrointestinal contraction amplitude mainly via a cholinergic pathway. 5HT3 receptors and 5HT1-like and/or 5HT2C receptors appear to be r...Continue Reading

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Citations

Jun 11, 2009·Bulletin of Experimental Biology and Medicine·A E Lychkova
Nov 14, 2003·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Cornelia WagnerJohn A Oaks
Dec 26, 2002·Japanese Journal of Pharmacology·Atsuko InuiTsugutaka Ito
Aug 31, 2007·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·R Spiller
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