Effect of 5 Hz repetitive transcranial magnetic stimulation on cognition during a Go/NoGo task

Journal of Psychiatric Research
Chih-Chia HuangI-Hua Wei

Abstract

Repetitive transcranial magnetic stimulation (rTMS) has been developed as a novel tool for modulating cognition by delivering stimulation in the brain. However, the effects of rTMS on cognition are still controversial. This randomized, sham-controlled, crossover study was designed to determine whether rTMS of the left dorsolateral prefrontal cortex (DLPFC) interferes with the Go/NoGo task and whether personal parameters such as age affect rTMS. A total of 24 healthy subjects (12 male and 12 female, aged 20-37 years) underwent one session of active rTMS followed by sham rTMS (total of 1600 pulses, 100% of motor threshold, 5 Hz, 8 s), or vice versa. The results did not show any differences between active and sham rTMS stimulation in terms of performance accuracy, response speed, or choice reaction time (cRT) implicating that short-term rTMS will not enhance or deteriorate cognition. However, percentage cRT shortening induced by active rTMS was negatively correlated with age (r = -0.57, P = 0.005), whereas that induced by sham rTMS was not (r = -0.23, P > 0.05), suggesting that cognition of younger subjects might have greater modulation by active stimulation than older ones. This finding may help explain some of the controversies ...Continue Reading

References

Apr 1, 1993·Electroencephalography and Clinical Neurophysiology·A Pascual-LeoneL G Cohen
Jan 1, 1996·Experimental Brain Research·A Pascual-LeoneM Hallett
Oct 1, 1996·Electroencephalography and Clinical Neurophysiology·E M WassermannM Hallett
Apr 21, 1998·The Journal of Neuropsychiatry and Clinical Neurosciences·G S FigielS Glover
Mar 18, 1999·Neuropsychologia·J Grafman, E Wassermann
Apr 12, 2000·Experimental Brain Research·M Jahanshahi, J Rothwell
Aug 24, 2000·The Journal of Neuropsychiatry and Clinical Neurosciences·F A KozelM S George
Feb 13, 2001·Human Brain Mapping·P F LiddleA M Smith
Aug 22, 2001·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·B R Mull, M Seyal
Sep 11, 2002·Neurology·S F CappaC Miniussi
Jan 16, 2003·Brain Research. Cognitive Brain Research·Felix M MottaghyBernd J Krause
May 3, 2003·The American Journal of Psychiatry·Ari A GershonLeon Grunhaus

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Citations

Oct 28, 2009·Journal of Neural Transmission·Birgit GuseThomas Wobrock
May 25, 2005·Journal of the Chinese Medical Association : JCMA·Chih-Chia HuangI-Hua Wei
Apr 22, 2010·American Journal of Physical Medicine & Rehabilitation·Bo Ryun KimJae Sung Kwon
Dec 22, 2009·Expert Review of Medical Devices·Rodrigo C L EdelmuthFelipe Fregni
May 8, 2018·Neuropsychology Review·Cheng-Chang YangNajat Khalifa
Jul 28, 2020·Schizophrenia Research. Cognition·Mehmet Diyaddin GülekenÖmer Akil Özer

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