PMID: 8946354Dec 1, 1996Paper

Effect of 6-aminonicotinamide on the pentose phosphate pathway: 31P NMR and tumor growth delay studies

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
J A KoutcherD S Martin

Abstract

6-aminonicotinamide (6AN) has been shown to enhance radiosensitivity in vitro, although previous in vivo studies failed to show an effect. 31P NMR spectra were obtained by using a one-dimensional chemical shift imaging technique on a first generation transplant of the CD8FI spontaneous mammary carcinoma tumor model. Spectra were obtained both before and 10 h after treatment with 6AN (20 mg/kg). Changes in pH, nucleoside triphosphate/inorganic phosphate, and phosphocreatine/ inorganic phosphate measured at 10 h post-6AN were not significant. A new peak was detected 10 h post-6AN, which was assigned to 6-phosphogluconate (6PG), indicating inhibition of the pentose phosphate pathway (PPP). Based on the spectral data demonstrating inhibition of the PPP at 10 h post-6AN, tumor-bearing mice were irradiated (15 Gy x 3 fractions) on Days 1, 10 or 11, and 21 10 h after administration of 6-aminonicotinamide (20 mg/kg). Tumor-bearing mice receiving 6AN alone (20 mg/kg x 3), radiation alone (15 Gy x 3), or saline were also studied. Tumor growth delay studies indicated that 6AN alone induced a small but significant tumor growth delay (4.3 +/- 0.8 days). Radiation alone induced a tumor growth delay of 34.5 +/- 2.7 days. Treatment with 6AN fo...Continue Reading

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Citations

Apr 5, 2001·International Journal of Radiation Oncology, Biology, Physics·S XuJ A Koutcher
Dec 10, 1997·International Journal of Radiation Oncology, Biology, Physics·J A KoutcherD S Martin
May 15, 2012·Free Radical Biology & Medicine·Chiara RigantiDario Ghigo
Mar 10, 2012·Radiation Research·Dominick J O McIntyreJohn R Griffiths
Jan 1, 2014·Physics in Medicine and Biology·Louisa BokachevaJason A Koutcher
Aug 31, 2017·Cancer & Metabolism·Nathan J LanningCarrie R Graveel
May 30, 2017·Frontiers in Oncology·Marta Anna KowalikAndrea Perra
Jan 15, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Claudio VimercatiFabio A Recchia
Nov 3, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Philip M TedeschiJoseph R Bertino

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