Effect of 6-month calorie restriction and exercise on serum and liver lipids and markers of liver function.

Obesity
D Enette Larson-MeyerPennington CALERIE team

Abstract

Nonalcoholic fatty liver disease (NAFLD) and its association with insulin resistance are increasingly recognized as major health burdens. The main objectives of this study were to assess the relation between liver lipid content and serum lipids, markers of liver function and inflammation in healthy overweight subjects, and to determine whether caloric restriction (CR) (which improves insulin resistance) reduces liver lipids in association with these same measures. Forty-six white and black overweight men and women (BMI = 24.7-31.3 kg/m(2)) were randomized to "control (CO)" = 100% energy requirements; "CR" = 25%; "caloric restriction and increased structured exercise (CR+EX)"= 12.5% CR + 12.5% increase in energy expenditure through exercise; or "low-calorie diet (LCD)" = 15% weight loss by liquid diet followed by weight-maintenance, for 6 months. Liver lipid content was assessed by magnetic resonance spectroscopy (MRS) and computed tomography (CT). Lipid concentrations, markers of liver function (alanine aminotransferase (ALT), alkaline phosphatase (ALK)), and whole-body inflammation (tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), high-sensitivity C-reactive protein (hsCRP)) were measured in fasting blood. At bas...Continue Reading

References

Nov 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·I R Wanless, J S Lentz
Jul 1, 1997·Journal of Hepatology·C RicciL Dalla Palma
May 29, 1999·Gastroenterology·C A MatteoniA J McCullough
Jul 21, 2000·The Journal of Clinical Investigation·G I Shulman
Jun 8, 2001·Proceedings of the National Academy of Sciences of the United States of America·J K KimG I Shulman
Jul 27, 2001·Diabetes·G MarchesiniN Melchionda
Dec 26, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·Anna Mae Diehl
Apr 19, 2002·The New England Journal of Medicine·Paul Angulo
Jul 11, 2002·The Journal of Clinical Endocrinology and Metabolism·Anneli Seppälä-LindroosHannele Yki-Järvinen
Sep 13, 2002·Obesity Research·Mirja TiikkainenHannele Yki-Järvinen
Apr 30, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Brent A Neuschwander-Tetri, Stephen H Caldwell
Mar 17, 2004·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·M BajajR A DeFronzo
May 29, 2004·The Journal of Biological Chemistry·Varman T SamuelGerald I Shulman
Aug 28, 2004·Clinics in Liver Disease·Jayanta Choudhury, Arun J Sanyal
Sep 2, 2004·American Journal of Physiology. Endocrinology and Metabolism·Lidia S SzczepaniakRobert L Dobbins
Nov 27, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jeffrey D BrowningHelen H Hobbs
Aug 4, 2005·Obesity Research·Yung-Hsuan ShenKuo-Chin Huang
Feb 24, 2006·Obesity·D Enette Larson-MeyerUNKNOWN Look AHEAD Adipose Research Group
Apr 6, 2006·JAMA : the Journal of the American Medical Association·Leonie K HeilbronnUNKNOWN Pennington CALERIE Team
Jan 4, 2007·The Journal of Clinical Endocrinology and Metabolism·Leanne M RedmanUNKNOWN Pennington CALERIE Team

❮ Previous
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Citations

Apr 18, 2013·Nature Reviews. Endocrinology·Riia K JunnilaJohn J Kopchick
Feb 18, 2010·Metabolic Syndrome and Related Disorders·Katherine Esposito, Dario Giugliano
Sep 12, 2012·Rejuvenation Research·Andrew R Mendelsohn, James W Larrick
Sep 8, 2010·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·David G Le CouteurRafael de Cabo
Dec 17, 2009·Current Opinion in Gastroenterology·Shelby Sullivan
Apr 13, 2012·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Fernando Tadeu Trevisan FrajacomoSérgio Britto Garcia
Aug 16, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Edward P Weiss, Luigi Fontana
Dec 24, 2011·Experimental Diabetes Research·Angela MazzaAntonino Belfiore
Aug 29, 2012·Oxidative Medicine and Cellular Longevity·Samo Ribarič
Nov 14, 2012·Therapeutic Advances in Endocrinology and Metabolism·Romina LomonacoKenneth Cusi
Oct 29, 2009·Endocrine Reviews·Ines Pagel-LangenickelMichael N Sack
Aug 12, 2014·World Journal of Gastroenterology : WJG·Luca MontesiGiulio Marchesini
May 9, 2012·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Yang DaiTie-Mei Zhang
Jan 16, 2014·The Proceedings of the Nutrition Society·Patrick Schrauwen, Silvie Timmers
Feb 28, 2009·Women's Health·Ayako Suzuki, Manal F Abdelmalek
May 20, 2014·International Journal of Molecular Sciences·Fatiha Nassir, Jamal A Ibdah
Jan 21, 2016·International Journal of Obesity : Journal of the International Association for the Study of Obesity·H ZhangX Wang
Jun 26, 2012·Trends in Endocrinology and Metabolism : TEM·Joris Hoeks, Patrick Schrauwen
Dec 1, 2009·Clinics in Geriatric Medicine·Emanuele MarzettiChristiaan Leeuwenburgh
Jul 17, 2013·Annals of the New York Academy of Sciences·Silvie TimmersPatrick Schrauwen
Feb 27, 2010·Obesity·Jonathan KrakoffUNKNOWN Diabetes Prevention Program Research Group
Nov 23, 2012·Journal of Magnetic Resonance Imaging : JMRI·Arian MashhoodNorah J Shire
Jun 11, 2010·European Journal of Clinical Investigation·Daniel L SmithDavid B Allison
Dec 31, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Elisa FabbriniSamuel Klein
Sep 24, 2015·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Melissa A LindenR Scott Rector
Apr 13, 2015·Journal of Hepatology·Shelley E KeatingNathan A Johnson
Mar 15, 2012·Journal of Hepatology·Shelley E KeatingNathan A Johnson
Mar 6, 2013·Free Radical Biology & Medicine·Yiqiang ZhangHolly Van Remmen
Apr 23, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jeffrey B Schwimmer
Dec 3, 2014·Biochimica Et Biophysica Acta·Marlies de LigtPatrick Schrauwen

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