Effect of 6-OHDA lesions on striatal mRNA levels encoding for glutamate receptor subunits

Neuroreport
M TremblayJ J Soghomonian

Abstract

Levels of mRNAs encoding for subunits of glutamate receptors were measured by in situ hybridization in the rat striatum after unilateral injections of 6-hydroxydopamine in the substantia nigra. When compared with the contralateral striatum, levels of NMDAR1, GluR1 and GluR2 mRNAs were significantly higher in the dopamine-deafferented striatum. Comparison with saline-injected rats showed that the NMDAR1 and the GluR1 mRNA labelling was increased in the striatum ipsilateral to the lesion. In contrast, GluR2 mRNA labelling in 6-OHDA-injected rats was not different from that in saline-injected rats. These results support the hypothesis that experimental dopamine deafferentation induces functional changes at the level of glutamatergic synapses in the striatum.

Citations

May 19, 1997·The Journal of Comparative Neurology·E M OstapoffR L Saint Marie
Nov 9, 2000·European Journal of Pharmacology·N JonkersY Michotte
Apr 2, 1998·Fundamental & Clinical Pharmacology·F Blandini, J T Greenamyre
Feb 28, 1997·The Journal of Biological Chemistry·G Bai, J W Kusiak

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