PMID: 7540812Jun 1, 1995Paper

Effect of 7.2% hypertonic saline/6% hetastarch on left ventricular contractility in anesthetized humans

Anesthesiology
A W GoertzM Georgieff

Abstract

Although a positive inotropic effect of hypertonic saline has been demonstrated in isolated cardiac tissue as well as in animal preparations, no information exists about a possible positive inotropic action of hypertonic saline in humans. The aim of this investigation was to determine whether a clinically relevant positive inotropic effect can be demonstrated in humans. Twenty-six patients without cardiovascular disease were randomized to receive 4 ml/kg of either 7.2% hypertonic saline/6% hetastarch or 6% hetastarch (control) at a rate of 1 ml.kg-1.min-1 while under general endotracheal anesthesia. Transesophageal echocardiography was used to evaluate left ventricular function. Arterial pressure, heart rate, and left ventricular end-systolic and end-diastolic diameter, area, and wall thickness were measured immediately before and after administration of either solution. Fractional area change, end-systolic wall stress, and the area under the end-systolic pressure-length relationship curve (ESPLRarea) were calculated. ESPLRarea was used to assess left ventricular contractility. Administration of hypertonic saline/hetastarch resulted in a significant decrease of mean arterial pressure and end-systolic wall stress from 77 +/- 14 ...Continue Reading

Associated Clinical Trials

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Citations

Nov 5, 1999·Critical Care Medicine·R G Johnson
Sep 16, 2000·Current Opinion in Nephrology and Hypertension·S S Waikar, G M Chertow
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