Abstract
9-(4-Hydroxybutyl)-N2-phenylguanine (HBPG) is a new viral thymidine kinase inhibitor that we tested for the ability to prevent recurrences of herpetic keratitis. Eighteen squirrel monkeys (Saimiri scuireus) were infected in both corneas with the Rodanus strain of herpes simplex virus type 1 (HSV-1). All corneas showed typical dendritic keratitis 3 days after infection, followed by spontaneous healing. On day 21, the monkeys were randomized into two coded groups and ocular examinations were begun. One group received intraperitoneal (i.p.) injections of HBPG, 150 mg/kg, in a corn oil suspension every 8 h, and the other group received i.p. injections of the corn oil vehicle only. On day 22, recurrences were induced by reducing the temperature of the room in the late afternoon so that a low of 18 degrees C was achieved during the night. After the morning treatment, room temperature was raised to the normal ambient temperature (24-27 degrees C), and treatment was discontinued. Treatment was reinstituted on day 27, the room temperature was lowered again on day 28, and treatment was again discontinued as before. Third and fourth cycles of treatment and cold stress were begun on days 34 and 69. Ocular examinations were continued until ...Continue Reading
References
Nov 1, 1979·The Journal of Infectious Diseases·N H ParkS L McLean
Sep 1, 1992·Antimicrobial Agents and Chemotherapy·N BourneL R Stanberry
Oct 1, 1991·Antiviral Research·H E KaufmanG E Dutschman
Oct 1, 1990·Antiviral Research·R J Klein, S M Czelusniak
Jun 1, 1990·Antimicrobial Agents and Chemotherapy·D A LeibD M Coen
Aug 1, 1990·Antimicrobial Agents and Chemotherapy·Y A NsiahF Rapp
Apr 23, 1988·Lancet·A MindelP Williams
Mar 1, 1987·Antimicrobial Agents and Chemotherapy·L M NutterY C Cheng
Jun 1, 1986·The British Journal of Ophthalmology·L M CollumP J Rees
Mar 1, 1987·Antimicrobial Agents and Chemotherapy·D Gold, L Corey
Dec 1, 1985·The British Journal of Dermatology·R H Meyrick ThomasJ D Kirby
Jul 14, 1984·Lancet·A MindelM W Adler
Jul 9, 1981·The New England Journal of Medicine·R SaralP S Lietman
Jun 3, 1982·The New England Journal of Medicine·L CoreyK K Holmes
Jun 14, 1984·The New England Journal of Medicine·S E StrausT Creagh-Kirk
Jun 14, 1984·The New England Journal of Medicine·J M DouglasL Corey
Jan 6, 1995·Journal of Medicinal Chemistry·H XuG E Wright
Apr 1, 1994·Antimicrobial Agents and Chemotherapy·J L TaylorW J O'Brien
May 1, 1994·Cornea·N P Barney, C S Foster
Feb 15, 1993·Annals of Internal Medicine·J F RooneyA L Notkins
May 1, 1996·Antiviral Research·B M GebhardtH E Kaufman
Feb 1, 1962·Proceedings of the Society for Experimental Biology and Medicine·H E KAUFMAN
Citations
Dec 30, 1999·Progress in Retinal and Eye Research·H E Kaufman
May 27, 2005·Journal of Medicinal Chemistry·Andrzej ManikowskiGeorge E Wright
Sep 29, 2000·Cornea·Y J Gordon
Mar 11, 2009·Current Eye Research·Shiro HigakiYoshikazu Shimomura
Oct 16, 2015·Antiviral Chemistry & Chemotherapy·Milka YanachkovaGeorge E Wright
Feb 16, 1999·FEBS Letters·M S BennettM R Sanderson
Jul 8, 1999·Journal of Medicinal Chemistry·H SunS Spadari
Jun 5, 2004·Journal français d'ophtalmologie·M Labetoulle