PMID: 8585791Jan 1, 1993Paper

Effect of a beta-agonist and a beta-agonist/beta-antagonist combination on muscle growth, body composition and protein metabolism in rats

Archiv für Tierernährung
K ReichelK Krawielitzki

Abstract

In 3 experimental groups 9 female Wistar rats (initial live weight 150 g) were fed either the control diet, the control diet supplemented with 5 mg clenbuterol or the combination of 5 mg clenbuterol and 500 mg propranolol per kg diet over a 12-day period. The N-balance was estimated over days 6 to 10 followed by a 15N-tracer experiment for determining the influence of the feed additives on characteristics of protein metabolism on day 12. All differences in the means were concluded to be significant for P < 0.05. Live weight gain and feed efficiency were improved by clenbuterol. The animals treated with clenbuterol had 18%-24% higher muscle weights whereas the combined treatment increased the muscle weights by 10%-16% only. The good correlation between the increase of muscle weights and the total protein content indicates that clenbuterol does not change the relation between protein- and water accumulation. Histological-histochemical investigations showed that the higher muscle weights were achieved through muscle fibre hypertrophy. The number of muscle fibres remained constant. Concerning the distribution of the fibre types, clenbuterol increased the proportion of FTG-fibres (white, fast-twitch, glycolytic) on the expense of th...Continue Reading

References

Oct 1, 1990·Domestic Animal Endocrinology·J M HarperP J Buttery
Jan 1, 1988·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·P J ReedsR M Palmer
Sep 1, 1989·Journal of Animal Science·W G BergenD B Anderson
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Jul 1, 1989·The Biochemical Journal·Y T Yang, M A McElligott
Jul 1, 1986·The British Journal of Nutrition·P J ReedsR M Palmer

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Citations

Feb 14, 2002·Journal of Applied Physiology·Wesley N SmithScott K Powers
Jan 1, 2015·Terapevticheskiĭ arkhiv·M F Ballyuzek, M V Mashkova
Jul 10, 2007·Journal of the American Medical Directors Association·Shing-Shing YehMichael W Schuster
Feb 24, 2009·Journal of Chromatography. a·Irmgard RiedmaierHeinrich H D Meyer

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