PMID: 8242250Oct 1, 1993Paper

Effect of a calcitonin gene-related peptide antagonist (CGRP8-37) on skin vasodilatation and oedema induced by stimulation of the rat saphenous nerve

British Journal of Pharmacology
K J Escott, S D Brain

Abstract

1. The effect of the calcitonin gene-related peptide antagonist (CGRP8-37, 400 nmol kg-1, i.v.) on the increased blood flow induced by calcitonin gene related peptide (CGRP), vasodilator prostaglandins, and topical capsaicin was measured with a laser Doppler blood flow meter in rat abdominal skin. 2. The saphenous nerve was electrically stimulated and the effect of CGRP8-37 (400 nmol kg-1, i.v.) on the increased blood flow (measured by laser Doppler flowmetry) and oedema formation (measured by the extravascular accumulation of [125I]-albumin) was investigated in the rat hind paw. 3. CGRP8-37 (400 nmol kg-1, i.v.) had no effect on basal cutaneous blood flow at uninjected sites and sites injected with Tyrode buffer, but acted selectively to inhibit the increased blood flow induced by intradermal CGRP (10 pmol/site, P < 0.05), but not that induced by prostaglandin E2 (PGE2, 300 pmol/site) or carba-prostacyclin (cPGI2, 100 pmol/site). 4. Capsaicin (0.1-33 mM), applied topically, acted in a dose-related manner to increase blood flow. CGRP8-37 (400 nmol kg-1, i.v.) almost totally inhibited blood flow induced by capsaicin (10 mM; P < 0.05) but did not significantly inhibit blood flow induced by a higher dose of capsaicin (33 mM). 5. T...Continue Reading

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Citations

Aug 10, 2012·Pflügers Archiv : European journal of physiology·Mária DuxGábor Jancsó
Sep 5, 1995·European Journal of Pharmacology·A AhluwaliaR J Flower
Apr 22, 1996·European Journal of Pharmacology·H CambridgeS D Brain
Jun 1, 1996·General Pharmacology·S D Brain, H Cambridge
Jul 1, 1996·British Journal of Plastic Surgery·T Iinuma, Y Sawada
Apr 23, 1997·European Journal of Pharmacology·E PintérJ Szolcsányi
Jun 5, 2003·Toxicon : Official Journal of the International Society on Toxinology·Paula R S CâmaraEdson Antunes
Apr 11, 2003·Neuroscience Letters·Ferenc DomokiGábor Jancsó
Jan 30, 2002·British Journal of Pharmacology·Andrew D GrantSusan D Brain
Jan 11, 2003·British Journal of Pharmacology·Masahiro NagahamaJun Sakurai
Aug 7, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Z KhalilB G Livett
Aug 1, 1995·British Journal of Pharmacology·A M ElhawaryC C Pang
Nov 1, 1995·British Journal of Pharmacology·P HolzerB A Peskar
Oct 11, 2005·Neuro-Signals·Louis Vera-Portocarrero, Karin N Westlund

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