PMID: 7009084Mar 1, 1981Paper

Effect of a calcium inhibitor, nifedipine, on exercise tolerance in patients with angina pectoris: a double-blind study

Chest
R CorbalanP Casanegra

Abstract

The effect of nifedipine on exercise tolerance was studied in 30 patients with stable angina and positive graded exercise testing. Treadmill exercise testing was performed on each of five consecutive days. Placebo or nifedipine, 10 mg sublingually, was given 30 minutes before exercise on the third day. The following day the intervention was reversed in a double-blind manner. Angina was abolished by nifedipine but not by placebo in 12 patients (40 percent). The time to onset of angina in the remaining patients increased from 4.1 +/- 0.4 (SEM) to 6.7 +/- 0.6 min (p less than .001). Time to ST depression greater than or equal to 2 mm increased from 4.0 +/- 0.3 to 5.4 +/- 0.5 min, while duration of exercise increased from 6.3 +/- 0.3 to 8.2 +/- 0.4 min (p less than .001). The maximum heart rate was 145 +/- 3.3 with nifedipine and 122 +/- 3.8 min-1 with placebo (p less than .01). Resting systolic blood pressure decreased 30 min after nifedipine administration from 131 +/- 3.4 to 106 +/- 2.9 mm Hg (p less than .01). Maximal systolic blood pressure during exercise was lower with nifedipine (127 +/- 4.8 mm Hg) than with placebo (155 +/- 5.6 mm Hg, p less than .01). We conclude that nifedipine significantly improves the exercise toleran...Continue Reading

References

Jan 1, 1972·Progress in Cardiovascular Diseases·R E Goldstein, S E Epstein
Mar 1, 1969·Progress in Cardiovascular Diseases·R A Bruce, T R Hornsten
Dec 1, 1969·Circulation·A N GoldbargG A Bermudez

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Citations

May 1, 1983·Progress in Cardiovascular Diseases·G J Goldman, A D Pichard
Jan 1, 1983·Pharmacology & Therapeutics·A G Ellrodt, B N Singh
Jan 1, 1983·Pharmacology & Therapeutics·W G Nayler, J D Horowitz
Mar 1, 1984·The American Journal of Cardiology·N S KhurmiE B Raftery
Dec 1, 1984·International Journal of Cardiology·G Di PasqualeG Pinelli
Mar 1, 1988·International Journal of Cardiology·E A RodriguesE B Raftery
Jan 1, 1982·International Journal of Cardiology·L G Ekelund
Feb 1, 1986·Clinical Cardiology·M Y FlugelmanM S Gotsman
Sep 1, 1984·The American Journal of Cardiology·M J O'HaraE B Raftery
Oct 1, 1982·The American Journal of Cardiology·M D WinnifordL D Hillis

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