Effect of a centrally active angiotensin-converting enzyme inhibitor, perindopril, on cognitive performance in a mouse model of Alzheimer's disease

Brain Research
Koji YamadaTomoyuki Kanda

Abstract

Angiotensin-converting enzyme (ACE) inhibitors have clinically been widely used as anti-hypertensive agents. In the present study, we compared the effects of a centrally active ACE inhibitor, perindopril, with those of non-centrally active ACE inhibitors, imidapril and enalapril, on cognitive performance in amyloid beta(Abeta) (25-35)-injected mice, a rodent model of Alzheimer's disease. We also determined the brain ACE activity in order to elucidate the relationship between the cognitive function and ACE inhibition in the brain. Abeta(25-35)-injected mice showed a cognitive impairment in spontaneous alteration and object recognition tests, the indices of immediate working memory and relatively long-term recognition memory, respectively. As indicated by these tests, the oral administration of perindopril (0.1, 0.3 or 1mg/kg/day) significantly reversed the cognitive impairment in these mice, whereas neither imidapril (0.3, 1 or 3mg/kg/day) nor enalapril (1, 3 or 10mg/kg/day) had any effect on cognitive performance. Perindopril (1mg/kg/day), imidapril (3mg/kg/day), or enalapril (10mg/kg/day) all inhibited the plasma ACE activities by more than 90%. Using the same dosing regimen, only perindopril inhibited the brain ACE activities...Continue Reading

References

Jun 26, 1986·The New England Journal of Medicine·S H CroogG H Williams
Mar 15, 1994·Biochemical and Biophysical Research Communications·A KlegerisP L McGeer
Jun 1, 1993·Pharmacology, Biochemistry, and Behavior·M J WaynerJ B Denny
Nov 20, 2004·Psychopharmacology·Daniel S KerrMartín Cammarota
Mar 1, 2005·The European Journal of Neuroscience·Ryutaro ObaHachiro Nakagawa
Apr 28, 2006·International Journal of Geriatric Psychiatry·Luca RozziniAlessandro Padovani
May 16, 2006·Hormones and Behavior·Juliana S BoniniMartín Cammarota
Oct 3, 2006·Neurobiology of Learning and Memory·Trisha Anne Jenkins, Siew Yeen Chai
Nov 30, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Dayong WangToshitaka Nabeshima
Aug 22, 2008·Biochemical and Biophysical Research Communications·Masaki MogiMasatsugu Horiuchi

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Citations

Mar 28, 2013·Drugs & Aging·Hitomi KurinamiRyuichi Morishita
Sep 12, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Maximilian WiesmannJurgen A H R Claassen
Jan 11, 2013·International Journal of Hypertension·Masaki MogiMasatsugu Horiuchi
Jan 1, 2015·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Tae-Wan Kim
Apr 12, 2012·Peptides·Ben-Shmuel SaritFleisher-Berkovich Sigal
Aug 27, 2016·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Nofar TorikaSigal Fleisher-Berkovich
Jan 28, 2014·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Kuldeep Singh ThakurPuneet Kumar Bansal
Sep 7, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Maximilian WiesmannJurgen Ahr Claassen
Mar 29, 2019·Exercise and Sport Sciences Reviews·Peter B RavenPaul J Fadel
Aug 18, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Nora HegazyAhmed Fahmy
Jul 25, 2019·Neurotoxicity Research·Mona KhalifaHala F Zaki
Jun 26, 2012·Geriatrics & Gerontology International·Masaki Mogi, Masatsugu Horiuchi
Jun 27, 2014·Metabolic Brain Disease·Aileen Marcelo, Gregory Bix
Mar 1, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Abdelrahman Y FoudaAdviye Ergul
Dec 12, 2020·Frontiers in Psychiatry·Fabio PanarielloAnna Rita Atti
Mar 4, 2021·Acta Physiologica·Kewarin JinawongSiriporn C Chattipakorn
Jul 12, 2011·Pharmacology, Biochemistry, and Behavior·Krzysztof ŁukawskiStanisław J Czuczwar
Jan 20, 2015·Journal of Agricultural and Food Chemistry·Leticia Mora, Maria Hayes
Sep 3, 2021·Computational and Structural Biotechnology Journal·Lucía Prieto SantamaríaAlejandro Rodríguez-González

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