May 1, 1989

Effect of a change in the effectiveness of a benzodiazepine-GABA-ionophore complex blockade on the reproduction of an amnesic memory trace in mice after preliminary diazepam administration

Zhurnal vyssheĭ nervnoĭ deiatelnosti imeni I P Pavlova
R Iu Il'iuchenokR I Parkhomenko

Abstract

The paper deals with the results of analysis of the influence of blocked of BD-GABA-ionophore complex and its separate components on recover of memory trace amnesia during BD-receptors activation in experiments on elaboration of CR of passive avoidance in mice. It is shown that at "neurochemical tuning" the improvement of conditioned reaction reproduction on the 2-nd and 21-st day after learning and amnestic action was observed only at GABAA receptor blockade by bicuculline, while the blockade of BD-receptor by flumazepil and of chlorine channel by picrotoxin was ineffective. Simultaneous blockade of all BD-GABA-ionophore complex components was not more effective in comparison with the blockade of its separate links in the recovery of conditioned reaction reproduction. The presented data allow to suppose that "psychogenic" amnesia development is determined by the functional state of neurotransmitter brain systems at learning and amnestic action which stipulates subsequent possibility of memory trace retrieval.

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Mentioned in this Paper

Avoidance Learning
Mice, Inbred BALB C
Reaction Time
Picrotoxin
Ion Channel
Amnestic State
GABA-A Receptor gamma Subunit
Conditioned Reflex
Valium
Chlorine

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