PMID: 9527357Apr 4, 1998Paper

Effect of a chlorhexidine/thymol-containing varnish on prostaglandin E2 levels in gingival crevicular fluid

European Journal of Oral Sciences
K SköldT Modéer

Abstract

The aim was to study the effect of a chlorhexidine/thymol-containing varnish (Cervitec) on the levels of prostaglandin E2 (PGE2) in gingival crevicular fluid (GCF). The material consisted of 25 adolescents and young adults with fixed orthodontic appliances exhibiting gingival inflammation. Four buccal sites, adjacent to bands and brackets, were selected on each patient and randomly treated with either a varnish containing chlorhexidine diacetate (1% w/w) and thymol (1% w/w) or a placebo varnish without active ingredients. After baseline registration, the varnishes were applied twice within 3 d. Follow-up examinations were performed after 3, 8 and 30 d. The gingival inflammation was assessed by bleeding on probing, volume of GCF with a Periotron 8000 and PGE2 level in GCF by using a radioimmuno assay. Compared with baseline, a statistically significant reduction in the volume of GCF was recorded at the chlorhexidine/thymol treated sites in contrast to the placebo. The mean PGE2 levels were significantly reduced after the test varnish treatment compared with baseline and differed significantly from placebo after 8 d. The findings suggest that treatments with the antibacterial varnish result in reduced gingival inflammation and ma...Continue Reading

Citations

Mar 23, 2004·European Journal of Pharmacology·János MagyarPéter P Nánási
Dec 9, 2003·Life Sciences·Norbert SzentandrássyIstván Jóna
May 16, 2002·British Journal of Pharmacology·János MagyarPéter P Nánási
Jul 17, 2003·BMC Pharmacology·Norbert SzentandrássyLászló Csernoch
Feb 16, 2002·Journal of Clinical Periodontology·S Matthijs, P A Adriaens
Feb 4, 2006·Drug Development and Industrial Pharmacy·Gian Carlo CeschelA Fini
Nov 26, 2015·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Jan SeibelJutta Haunschild
Jul 7, 2005·Journal of Clinical Periodontology·Jan CosynMehran Moradi Sabzevar
Jul 21, 2004·Toxicology Letters·Ana Paula Negrelo NewtonMaria Benigna Martinelli de Oliveira
Mar 24, 2005·Journal of Orthodontics·D T MillettD Devine
Jul 19, 2016·Oral Diseases·S Sommakia, O J Baker
Mar 22, 2007·Journal of Medical Microbiology·Antonia NostroAnna Rita Blanco

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