Effect of a combined oral contraceptive containing 20 microg ethinyl estradiol and 75 microg gestodene on hemostatic parameters

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
Jose Mendes AldrighiLuis Bahamondes

Abstract

The effects of a combined oral contraceptive (COC) containing 20 microg ethinyl estradiol (EE) and 75 microg gestodene (GSD) on prothrombin activity (PA), activated partial thromboplastin time (APTT), thrombin time (TT), platelet number, fibrinogen, antithrombin III (ATIII), protein C, protein S and D-dimer were evaluated over 6 months in 23 young, healthy women. Laboratory assessments were performed prior to initiation of COC use (pretreatment) and after 3 and 6 months of use. Results showed no significant changes in fibrinogen, protein C, ATIII or D-dimer during COC use, compared with pretreatment values. The increase in platelet count, decreases in protein S level, PA and APTT, and the prolongation of TT were significant. In conclusion, the use of a COC containing 20 microg EE and 75 microg GSD did not cause any significant changes in the hemostatic parameters studied that could be suggestive of a higher prothrombotic risk. Further studies with a larger sample size are necessary in order to obtain conclusive data.

References

Apr 1, 1975·Thrombosis Research·O R OdegardU Abildgaard
Oct 1, 1992·American Journal of Obstetrics and Gynecology·B M Alving, P C Comp
Oct 1, 1992·Contraception·F FruzzettiP Fioretti
Jul 1, 1990·American Journal of Obstetrics and Gynecology·R AbbateG Mariani
Jul 15, 1985·American Journal of Obstetrics and Gynecology·J P Realini, J W Goldzieher
Jan 1, 1993·American Journal of Obstetrics and Gynecology·K R PetersenJ Jespersen
Mar 1, 1993·Advances in Contraception : the Official Journal of the Society for the Advancement of Contraception·S O SkoubyK P Petersen
Mar 7, 1998·Baillière's Clinical Obstetrics and Gynaecology·L A Norris, J Bonnar
Jun 16, 1999·American Journal of Obstetrics and Gynecology·F Fruzzetti
Feb 1, 2000·Human Reproduction Update·J Conard
Mar 22, 2000·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·R N PrasadS S Ratnam
Mar 22, 2000·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·R L Bick, J Rice
Jul 18, 2002·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·A GirolamiE Zanon
Dec 13, 2003·Maturitas·Adolf E Schindler
Dec 18, 2003·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·M J van der MoorenC Kluft

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Citations

Jul 17, 2008·Expert Opinion on Pharmacotherapy·Ekaterina Uchikova, Blagovest Pehlivanov
Mar 1, 2015·Journal of Thrombosis and Thrombolysis·Stephan Moll
Jan 26, 2012·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Kyle R BrandyAfshin A Divani
Oct 27, 2018·Microscopy Research and Technique·Albe Carina SwanepoelJanette Bester
Jul 18, 2017·Expert Review of Clinical Pharmacology·Manuela FarrisGiuseppe Benagiano
Oct 21, 2020·Seminars in Thrombosis and Hemostasis·Jonathan DouxfilsCéline Bouvy

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