Effect of a concomitant urologic procedure on outcomes following cytoreductive surgery with hyperthermic intraperitoneal chemotherapy

Journal of Surgical Oncology
Timothy D LyonBenjamin J Davies

Abstract

To evaluate whether urologic procedures during cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) are associated with adverse postoperative outcomes. We identified patients who underwent CRS-HIPEC at our institution from 2001 to 2012 and compared outcomes between operations that did and did not include a urologic procedure. A total of 938 CRS-HIPEC procedures were performed, 71 of which included a urologic intervention. Urologic interventions were associated with longer operative times (547 vs. 459 min, P < 0.001) and greater length of stay (15 vs. 12 days, P = 0.003). Major complications (Clavien III and IV) were more common in the urologic group (31% vs. 20%, P = 0.028). On multivariable analysis, urologic procedures were associated with a low anterior resection (OR: 2.25, 95%CI 1.07-4.74, P = 0.033) and a greater number of enteric anastomoses (OR: 1.83, 95%CI 1.31-2.56, P < 0.001). At a median follow up of 17 months (IQR 5.6-35 months), addition of a urologic procedure did not significantly impact overall survival for appendiceal or colorectal cancers. Urologic surgery at the time of CRS-HIPEC is associated with longer operative times, length of stay and increased risk of major complications, bu...Continue Reading

References

Feb 11, 2005·International Seminars in Surgical Oncology : ISSO·Rhonda L Harmon, Paul H Sugarbaker
Dec 15, 2005·Journal of Surgical Oncology·R M SmeenkF A N Zoetmulder
Jan 25, 2007·International Journal of Colorectal Disease·J O W PelzT Meyer
Jun 27, 2009·The Cancer Journal·Philip Bao, David Bartlett
Mar 5, 2013·Annals of Surgical Oncology·Patrick L WagnerHaroon A Choudry

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