Effect of a controlled-release chlorhexidine chip on clinical and microbiological parameters and prostaglandin E2 levels in gingival crevicular fluid

Journal of Periodontology
Tansel MizrakFikret Ipek

Abstract

The aim of the present study was to determine the effect of a chlorhexidine chip on crevicular prostaglandin E2 (PGE2) levels and on the clinical and microbiological parameters of periodontitis when used as adjunctive therapy to scaling and root planing (SRP) in patients with chronic periodontitis. This randomized single-blind study was carried out in parallel design. The test group received SRP plus chlorhexidine chip, whereas the control group received SRP alone. Thirty-four subjects, aged 20 to 55 years, with chronic periodontitis were recruited. Clinical indices, microbiological samples, and gingival crevicular fluid (GCF) samples were evaluated at baseline and after 1, 3, and 6 months. Microbiological samples were evaluated under a light microscope. GCF PGE2 levels were determined using radioimmunoassay. Significant improvements could be found for all clinical variables in both groups over the study period. The mean changes in probing depth obtained by SRP plus chlorhexidine chip were greater than those obtained by the SRP alone group at 3 and 6 months. In the test group, there was also significant gain in clinical attachment level at 6 months. When data were combined from all groups, significant reductions in GCF PGE2 lev...Continue Reading

References

Oct 1, 1979·Journal of Clinical Periodontology·J Slots
Dec 1, 1992·Journal of Periodontology·R R Ranney
Nov 1, 1986·Journal of Periodontal Research·T C QueeE C Chan
Apr 1, 1989·Journal of Clinical Periodontology·A StanleyH N Newman
Apr 1, 1987·British Medical Bulletin·J A Salmon, G A Higgs
Mar 1, 1986·Journal of Periodontal Research·S OffenbacherT E Van Dyke
Jun 1, 1986·Journal of Periodontology·G GreensteinR Jaffin
Nov 1, 1967·Journal of Periodontology·H Löe
Aug 1, 1981·Journal of Clinical Periodontology·S OffenbacherJ M Goodson
May 1, 1993·Journal of Periodontology·S OffenbacherJ G Collins
Nov 1, 1996·Annals of Periodontology·S Offenbacher
Oct 26, 1999·Journal of Periodontology·P M PreshawP A Heasman
Feb 16, 2000·Journal of Clinical Periodontology·L RasmussenU H Lerner
Jun 23, 2000·Annals of Periodontology·G C Armitage
Jan 6, 2001·Journal of Clinical Periodontology·P A HeasmanG I McCracken
Oct 9, 2002·Journal of Periodontal Research·Nazanin DaneshmandJørgen Slots
Nov 26, 2002·Journal of Clinical Periodontology·Daniela C GrisiMárcio F M Grisi
Jun 12, 2004·Journal of Clinical Periodontology·Renate DeinzerArmin Herforth
May 1, 1993·Journal of Periodontology·Steven OffenbacherJohn G Collins
Dec 1, 1992·Journal of Periodontology·Richard R Ranney

❮ Previous
Next ❯

Citations

Aug 7, 2014·Journal of Natural Science, Biology, and Medicine·A Jana KumarVijay K Chava
Jul 27, 2015·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·S PattnaikA Satpathy
Sep 4, 2016·BMC Oral Health·Fabienne A GerberPatrick R Schmidlin
Jul 22, 2017·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Abhilasha SinghAkash Mandloy
Nov 1, 2011·Journal of Investigative and Clinical Dentistry·Khizer MohiuddinByadarahalli Raju Smitha
Apr 24, 2012·International Journal of Dental Hygiene·J CosynH De Bruyn

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.