Effect of a cyclooxygenase-2 inhibitor on postexercise muscle protein synthesis in humans.

American Journal of Physiology. Endocrinology and Metabolism
N A BurdT A Trappe

Abstract

Nonselective blockade of the cyclooxygenase (COX) enzymes in skeletal muscle eliminates the normal increase in muscle protein synthesis following resistance exercise. The current study tested the hypothesis that this COX-mediated increase in postexercise muscle protein synthesis is regulated specifically by the COX-2 isoform. Sixteen males (23 +/- 1 yr) were randomly assigned to one of two groups that received three doses of either a selective COX-2 inhibitor (celecoxib; 200 mg/dose, 600 mg total) or a placebo in double-blind fashion during the 24 h following a single bout of knee extensor resistance exercise. At rest and 24 h postexercise, skeletal muscle protein fractional synthesis rate (FSR) was measured using a primed constant infusion of [(2)H(5)]phenylalanine coupled with muscle biopsies of the vastus lateralis, and measurements were made of mRNA and protein expression of COX-1 and COX-2. Mixed muscle protein FSR in response to exercise (P < 0.05) was not suppressed by the COX-2 inhibitor (0.056 +/- 0.004 to 0.108 +/- 0.014%/h) compared with placebo (0.074 +/- 0.004 to 0.091 +/- 0.005%/h), nor was there any difference (P > 0.05) between the placebo and COX-2 inhibitor postexercise when controlling for resting FSR. The CO...Continue Reading

References

Apr 20, 1977·European Journal of Clinical Pharmacology·M D RawlinsA R Hijab
Aug 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·T Hla, K Neilson
Feb 1, 1990·Prostaglandins, Leukotrienes, and Essential Fatty Acids·R M Palmer
Aug 1, 1990·The American Journal of Physiology·H H VandenburghJ Shansky
Dec 15, 1989·Biochemical and Biophysical Research Communications·C Yokoyama, T Tanabe
Nov 15, 1994·Archives of Biochemistry and Biophysics·M D PercivalG P O'Neill
Dec 1, 1995·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·J D MacDougallK E Yarasheski
Jul 1, 1997·The American Journal of Physiology·S M PhillipsR R Wolfe
Mar 27, 1998·Clinical Pharmacokinetics·N M Davies
Aug 11, 2001·The New England Journal of Medicine·G A FitzGerald, C Patrono
Sep 18, 2001·JAMA : the Journal of the American Medical Association·E VolpiR R Wolfe
Oct 16, 2001·The Journal of Clinical Endocrinology and Metabolism·T A TrappeW J Evans
Feb 8, 2002·American Journal of Physiology. Endocrinology and Metabolism·T A TrappeW J Evans
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Sep 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·N V ChandrasekharanDaniel L Simmons
Feb 5, 2003·Current Medical Research and Opinion·Stefania TacconelliPaola Patrignani
Apr 16, 2003·The Journal of Cell Biology·Valerie Horsley, Grace K Pavlath
Nov 25, 2003·Oral Diseases·J SudbøM Bryne
Jan 7, 2004·Acta Physiologica Scandinavica·P A TeschJ T Trieschmann
Feb 24, 2004·Annual Review of Physiology·Michael J RennieFrank W Booth
Apr 16, 2004·American Journal of Physiology. Cell Physiology·Brenda A BondesenGrace K Pavlath
Jul 9, 2004·Biochemical and Biophysical Research Communications·Bozena Jemiolo, Scott Trappe
Aug 20, 2004·Pharmacological Reviews·Daniel L SimmonsTimothy Hla
Sep 4, 2004·Genome Biology·N V Chandrasekharan, Daniel L Simmons
Sep 17, 2004·Muscle & Nerve·Christopher L MendiasRonald E Allen
Sep 29, 2004·Acta Physiologica Scandinavica·T A TrappeP A Tesch
Oct 28, 2004·American Journal of Physiology. Endocrinology and Metabolism·Chad C CarrollTodd A Trappe
May 10, 2005·The Journal of Pharmacology and Experimental Therapeutics·Bela KisDavid W Busija
Sep 6, 2005·The Journal of Pharmacology and Experimental Therapeutics·Ning QinChristopher M Flores
Sep 20, 2005·Experimental Cell Research·Jeffrey S OtisGrace K Pavlath
Dec 17, 2005·Journal of Applied Physiology·V M DupouyH P Lefebvre
Jan 21, 2006·The Journal of Nutrition·Robert R Wolfe
Feb 10, 2006·American Journal of Physiology. Cell Physiology·Brenda A BondesenGrace K Pavlath
Mar 8, 2006·Prostaglandins, Leukotrienes, and Essential Fatty Acids·T TrappeR Hickner
May 5, 2006·Medicine and Science in Sports and Exercise·Quinlyn A SoltowDavid S Criswell

❮ Previous
Next ❯

Citations

Dec 12, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Todd A TrappeScott W Trappe
Dec 17, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Todd A TrappeChris J Hollon
Feb 18, 2011·Expert Opinion on Emerging Drugs·Stefan M Gehrig, Gordon S Lynch
Mar 16, 2013·Prostaglandins, Leukotrienes, and Essential Fatty Acids·R A StandleyT A Trappe
Aug 21, 2015·Neurochemical Research·Nakul P ThakoreNaren L Banik
Jun 16, 2009·Scandinavian Journal of Medicine & Science in Sports·G PaulsenT Raastad
Apr 12, 2016·Frontiers in Physiology·Luke VellaAaron P Russell
Nov 19, 2015·Journal of the International Society of Sports Nutrition·Kyle LeversRichard B Kreider
Apr 7, 2016·Journal of the International Society of Sports Nutrition·X CapóA Pons
Feb 9, 2017·Free Radical Research·Rômulo Pillon BarcelosGuilherme Bresciani
Feb 25, 2017·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Rômulo Pillon BarcelosJavier González-Gallego
Jun 10, 2016·The American Journal of Sports Medicine·Sarah Ilkhanipour RooneyLouis J Soslowsky
Jan 10, 2018·Proceedings of the National Academy of Sciences of the United States of America·David Møbjerg KristensenBernard Jégou
Jan 1, 2010·Annals of Nutrition & Metabolism·Kevin D Tipton
Mar 26, 2014·International Journal of Sports Physiology and Performance·Daniel H SerraviteJoseph F Signorile
Aug 14, 2018·Scandinavian Journal of Medicine & Science in Sports·Tommy R Lundberg, Glyn Howatson
May 3, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Chad C CarrollRayna J Gonzales
Oct 4, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·James F MarkworthDavid Cameron-Smith
Aug 20, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Matthew P HarberPaul T Reidy
Jul 16, 2019·Journal of Cachexia, Sarcopenia and Muscle·Ana Anoveros-BarreraVera C Mazurak
Mar 30, 2013·Journal of Applied Physiology·Maria L Urso
May 18, 2013·Journal of Applied Physiology·Abigail L Mackey
Oct 12, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Ligia M Antunes-CorreaCarlos E Negrao
Nov 27, 2015·Journal of Applied Physiology·Sophia Z LiuTodd A Trappe
May 16, 2015·Journal of Applied Physiology·Jonathan M PeakeVernon G Coffey
May 1, 2018·Journal of Animal Physiology and Animal Nutrition·W PearsonJ MacNicol
Aug 27, 2010·Scandinavian Journal of Medicine & Science in Sports·U R MikkelsenK M Heinemeier
Mar 30, 2013·Journal of Applied Physiology·Todd A Trappe, Sophia Z Liu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biomechanics

Biomechanics examines the generation of internal forces within the body and investigates the effects and control of forces that act on or are produced on tissues. Here are the latest discoveries.

Related Papers

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
T A TrappeChris Hollon
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Ulrika RaueScott Trappe
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
E M WeinheimerT A Trappe
© 2022 Meta ULC. All rights reserved