To determine the efficacy of digitalis drugs in suppressing ventricular ectopic activity, 142 patients with frequent (greater than 1 per minute) ventricular premature beats underwent acetyl strophanthidin tolerance testing. In 65 patients (46 per cent), frequency and grade were reduced during testing. In 37 (26 per cent), the ectopic activity remained unaltered; frequency increased during testing in the remaining 40 patients (28 per cent). In the group with a suppressive effect, ventricular premature beats decreased by 82 per cent, with complete abolition of arrhythmias in 46 per cent. The three groups were not distinguishable clinically by either the type or the extent of heart disease. The antiarrhythmic action of acetyl strophanthidin did not appear to depend upon its positive inotropic action. In some patients it appears to be due to an indirect reduction of Purkinje-fiber automaticity resulting from enhanced vagus-nerve activity that thereby lessens adrenergic tone on the heart.
Effect of vagus nerve stimulation upon excitability of the canine ventricle. Role of sympathetic-parasympathetic interactions
Muscarinic effects of vagosympathetic trunk stimulation on the repetitive extrasystole (RE) threshold
Basis for recurring ventricular fibrillation in the absence of coronary heart disease and its management
The effect of vagus nerve stimulation upon vulnerability of the canine ventricle: role of sympathetic-parasympathetic interactions
Ventricular electrical instability in the conscious dog: effects of psychologic stress and beta adrenergic blockade
Effect of vagal stimulation on the overflow of norepinephrine into the coronary sinus during cardiac sympathetic nerve stimulation in the dog
Prognostic importance of premature beats following myocardial infarction. Experience in the coronary drug project
Prognostic significance of ventricular ectopic beats with respect to sudden death in the late postinfarction period
Long-term survival of patients with malignant ventricular arrhythmia treated with antiarrhythmic drugs
Absence of cardioversion-induced ventricular arrhythmias in patients with therapeutic digoxin levels
Comparison of the canine tissue distribution of digoxin after acute and chronic administration: implications for digitalis therapy
Prediction of appropriate defibrillator therapy in heart failure patients treated with cardiac resynchronization therapy
Left ventricular dysfunction and altered autonomic activity: a possible link to sudden cardiac death
The relative effects of digoxin and diltiazem upon ventricular ectopic activity in patients with chronic atrial fibrillation
Digoxin uptake into peripheral autonomic cardiac nerves: possible mechanism of digitalis-induced antiarrhythmic and toxic electrophysiologic actions
The assessment of an antiarrhythmic agent, sustained-release procainamide, with the aid of Holter monitoring.
Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.
Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.