Effect of a digitalis drug on ventricular premature beats

The New England Journal of Medicine
B LownC E Gaughan

Abstract

To determine the efficacy of digitalis drugs in suppressing ventricular ectopic activity, 142 patients with frequent (greater than 1 per minute) ventricular premature beats underwent acetyl strophanthidin tolerance testing. In 65 patients (46 per cent), frequency and grade were reduced during testing. In 37 (26 per cent), the ectopic activity remained unaltered; frequency increased during testing in the remaining 40 patients (28 per cent). In the group with a suppressive effect, ventricular premature beats decreased by 82 per cent, with complete abolition of arrhythmias in 46 per cent. The three groups were not distinguishable clinically by either the type or the extent of heart disease. The antiarrhythmic action of acetyl strophanthidin did not appear to depend upon its positive inotropic action. In some patients it appears to be due to an indirect reduction of Purkinje-fiber automaticity resulting from enhanced vagus-nerve activity that thereby lessens adrenergic tone on the heart.

References

Apr 7, 1975·JAMA : the Journal of the American Medical Association·B LownH W Besser
Jun 1, 1975·American Heart Journal·T WeissK Engelman
Jul 1, 1971·Circulation·B Lown, M Wolf
Jun 1, 1973·Circulation·B D KosowskyR F Ritchie
Oct 1, 1973·Circulation·B LownP Brooks
Oct 1, 1974·Circulation·M B WaxmanC H Felderhof
Sep 1, 1972·The American Journal of Cardiology·B LownH Garrison
Nov 1, 1969·The American Journal of Cardiology·L E HinkleM Stevens
Nov 27, 1969·The New England Journal of Medicine·T W SmithE Haber
May 6, 1954·The New England Journal of Medicine·B LOWN, S A LEVINE
May 1, 1961·Circulation·B LOWN, S A LEVINE
Jun 1, 1960·The Journal of Clinical Investigation·J ROSSE BRAUNWALD

❮ Previous
Next ❯

Citations

Apr 1, 1993·Pediatric Pulmonology·C Van den BorreA Naessens
Sep 1, 1982·The American Journal of Cardiology·T B GraboysR DeSilva
Jul 15, 1979·European Journal of Pharmacology·W W BrooksB Lown
May 26, 1977·The American Journal of Cardiology·B LownS H Rabinowitz
Feb 1, 1979·The American Journal of Cardiology·B Lown
Mar 1, 1983·The American Journal of Cardiology·A H GradmanB L Zaret
Jan 1, 1983·Journal of the American College of Cardiology·B Surawicz
Apr 1, 1985·Journal of the American College of Cardiology·D L MannM M LeWinter
May 19, 1977·The New England Journal of Medicine
Feb 14, 2014·Journal of Cardiothoracic Surgery·Nizar R AlwaqfiAhmad Abu Baker
Oct 1, 1982·Journal of Electrocardiology·A L Goldberger, G P Curtis
Jan 28, 2010·The American Journal of Cardiology·Osama I I SolimanMarcel L Geleijnse
May 1, 1984·Progress in Cardiovascular Diseases·T W SmithJ D Marsh
Mar 1, 1984·Progress in Cardiovascular Diseases·T W SmithJ D Marsh
Oct 1, 1985·Journal of Clinical Pharmacology·B Levitt, D L Keefe
May 26, 1977·The American Journal of Cardiology·B Lown, T B Graboys
Jun 4, 1992·The American Journal of Cardiology·P J PodridT T Fuchs
Jun 24, 2004·Circulation·Mihai GheorghiadeWilson S Colucci
Oct 1, 1980·Circulation·M B WaxmanA D Sharma
Jun 1, 1986·Postgraduate Medicine·R J SimpsonL S Gettes
Jul 1, 1984·Progress in Cardiovascular Diseases·T W SmithJ D Marsh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

© 2021 Meta ULC. All rights reserved