PMID: 8512395Jun 1, 1993Paper

Effect of a free radical scavenger on cadaver lung transplantation

The Annals of Thoracic Surgery
Thomas M EganB R Wilcox


The pulmonary donor pool would increase substantially if lungs could be safely transplanted after cessation of circulation. To determine whether the addition of the free radical scavenger dimethylthiourea to the perfusate of cadaver lungs could improve graft function, canine donors were sacrificed, and lungs retrieved 2 hours after death. In a blinded fashion, dimethylthiourea was added to the modified Euro-Collins solution and infused into recipients (n = 9) perioperatively; a placebo was included in the perfusate of control animals (n = 9). Donor animals were ventilated with 100% oxygen only during flush and harvest. Recipients were rendered dependent upon the single left transplanted lung by occlusion of the right pulmonary artery and bronchus 1 hour after transplantation. Ventilation was maintained at a constant inspiratory oxygen fraction of 0.4. Recipients were followed up for 8 hours or until death. Three of 9 control animals survived the 8-hour observation period, whereas 6 of 9 recipients of cadaver lungs harvested with dimethylthiourea survived the observation period. Two deaths in the dimethylthiourea group occurred after 7 hours, implying that the effects of the ischemia and reperfusion injury were ameliorated by th...Continue Reading


Apr 11, 1992·The Annals of Thoracic Surgery·T M EganB R Wilcox
Oct 9, 1991·JAMA : the Journal of the American Medical Association·E P TrulockC M Dresler
Aug 1, 1990·The Annals of Thoracic Surgery·F C DetterbeckB R Wilcox
Apr 1, 1989·The Journal of Surgical Research·D E PaullB R Wilcox
Feb 1, 1989·The Annals of Thoracic Surgery·D E PaullB R Wilcox
Jan 17, 1985·The New England Journal of Medicine·J M McCord
Apr 1, 1988·Mayo Clinic Proceedings·P A Southorn, G Powis
Jul 1, 1952·Annals of Surgery·B BLADESR THISTLETHWAITE

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Sep 1, 1996·The Annals of Thoracic Surgery·M YamashitaG A Patterson
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Jan 22, 2004·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Thomas M Egan
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