PMID: 8512395Jun 1, 1993Paper

Effect of a free radical scavenger on cadaver lung transplantation

The Annals of Thoracic Surgery
Thomas M EganB R Wilcox

Abstract

The pulmonary donor pool would increase substantially if lungs could be safely transplanted after cessation of circulation. To determine whether the addition of the free radical scavenger dimethylthiourea to the perfusate of cadaver lungs could improve graft function, canine donors were sacrificed, and lungs retrieved 2 hours after death. In a blinded fashion, dimethylthiourea was added to the modified Euro-Collins solution and infused into recipients (n = 9) perioperatively; a placebo was included in the perfusate of control animals (n = 9). Donor animals were ventilated with 100% oxygen only during flush and harvest. Recipients were rendered dependent upon the single left transplanted lung by occlusion of the right pulmonary artery and bronchus 1 hour after transplantation. Ventilation was maintained at a constant inspiratory oxygen fraction of 0.4. Recipients were followed up for 8 hours or until death. Three of 9 control animals survived the 8-hour observation period, whereas 6 of 9 recipients of cadaver lungs harvested with dimethylthiourea survived the observation period. Two deaths in the dimethylthiourea group occurred after 7 hours, implying that the effects of the ischemia and reperfusion injury were ameliorated by th...Continue Reading

References

Apr 11, 1992·The Annals of Thoracic Surgery·T M EganB R Wilcox
Oct 9, 1991·JAMA : the Journal of the American Medical Association·E P TrulockC M Dresler
Aug 1, 1990·The Annals of Thoracic Surgery·F C DetterbeckB R Wilcox
Apr 1, 1989·The Journal of Surgical Research·D E PaullB R Wilcox
Feb 1, 1989·The Annals of Thoracic Surgery·D E PaullB R Wilcox
Jan 17, 1985·The New England Journal of Medicine·J M McCord
Apr 1, 1988·Mayo Clinic Proceedings·P A Southorn, G Powis
Jul 1, 1952·Annals of Surgery·B BLADESR THISTLETHWAITE

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Citations

Sep 1, 1996·The Annals of Thoracic Surgery·M YamashitaG A Patterson
Feb 13, 2001·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·S OkimasaT Asahara
Jan 22, 2004·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Thomas M Egan
Feb 6, 2004·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Cristiano Feijó AndradePaulo Francisco Guerreiro Cardoso
Jan 1, 1995·Annals of Surgery·R D Davis, M K Pasque
Apr 15, 1996·Transplantation·M H HenningtonT M Egan
Apr 1, 1996·The Annals of Thoracic Surgery·M YamashitaG A Patterson
Jul 15, 2015·Oxidative Medicine and Cellular Longevity·Renata Salatti Ferrari, Cristiano Feijó Andrade
May 27, 2005·The Journal of Surgical Research·Seiki TakashimaThomas M Egan
Jan 1, 1996·The Journal of Thoracic and Cardiovascular Surgery·G WuS Chien
Nov 1, 1996·The Journal of Thoracic and Cardiovascular Surgery·M YamashitaG A Patterson
Jan 1, 1995·Fundamental & Clinical Pharmacology·F Bolaños-JiménezG Fillion
Sep 18, 2008·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Eduardo Sperb PillaPaulo Francisco Guerreiro Cardoso
Jul 1, 1996·The Annals of Thoracic Surgery·R J NovickJ Lee
Jul 1, 1996·The Annals of Thoracic Surgery·M C MauneyC G Tribble
Sep 1, 1996·The Journal of Thoracic and Cardiovascular Surgery·C S RobertsT M Egan

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