PMID: 8941867Oct 1, 1996Paper

Effect of a herbomineral preparation D-400 in streptozotocin-induced diabetic rats

Journal of Ethnopharmacology
S K MitraM B Sujatha

Abstract

This study was undertaken to investigate the effect of D-400, a herbomineral formulation on blood sugar and other biochemical parameters in streptozotocin-induced diabetic rats. There was significant reduction in blood urea nitrogen, serum creatinine and serum uric acid levels in the D-400-treated group and considerable lowering of AUC in oral glucose tolerance test (OGTT). The D-400-treated group showed significant lowering of triglycerides and HDL cholesterol. There was a rise in hepatic glycogen level close to normal after D-400 treatment. In the pancreas of diabetic rats, D-400 therapy showed significant increase in islet number and beta cell count and appeared to bring about blood sugar homoeostasis by increasing insulin secretion and repair/regeneration of endocrine pancreas.

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Citations

Jan 18, 2002·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·L Pari, G Saravanan
Jul 27, 2007·Journal of Medicinal Food·Vaiyapuri SivajothiBalasubramanian Rajkapoor
Jul 27, 2007·Journal of Medicinal Food·Bartholomew I C BraiP U Agomo
May 24, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Chutwadee KrisanapunSeung Joon Baek
Jun 23, 2005·BMC Complementary and Alternative Medicine·Ramalingam Saravanan, Leelavinothan Pari
Mar 20, 2010·Canadian Journal of Physiology and Pharmacology·Md SalahuddinNavneet B Gadge
Nov 5, 2004·The Journal of Pharmacy and Pharmacology·P Subash Babu, P Stanely Mainzen Prince
Jun 24, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Aditya AryaMohd Rais Mustafa
Dec 9, 2014·TheScientificWorldJournal·Mazen M Jamil Al-ObaidiGoot Heah Khor
Mar 15, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Arumugam Sathya, Perumal Siddhuraju
Oct 28, 2018·Journal of Basic and Clinical Physiology and Pharmacology·Godwin C AkuodorDaniel Oj Aja
Sep 18, 2020·Journal of Complementary & Integrative Medicine·Sushil Bhargava, Mamta B Shah

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