PMID: 1391425Jan 1, 1992Paper

Effect of a high concentration perfluorocarbon emulsion on platelet function

Biomaterials, Artificial Cells, and Immobilization Biotechnology : Official Journal of the International Society for Artificial Cells and Immobilization Biotechnology
D Smith, T A Lane

Abstract

Perfluorocarbon (PFC) and lipid emulsions (eg. Fluosol, Intralipid,) containing phospholipid have been reported to modify platelet function after intravenous infusion. Platelet activation might be responsible for the generation of mediators responsible for PFC-induced side effects. In view of this, we investigated the effect of a highly concentrated perfluorocarbon emulsion containing 90% (w/v) perfluorooctylbromide (perflubron; PFOB), on porcine and human platelet activation and function. We measured both: a) stimulated ex-vivo porcine platelet aggregation pre and post infusion of either perflubron or control (vehicle only) emulsions, and b) stimulated in vitro human platelet calcium flux in the presence of perflubron emulsion or control emulsions. Platelet aggregation stimulated by collagen, ADP or arachidonic acid (AA) was inhibited in ex-vivo porcine platelets following infusion of perflubron emulsion at a dose of 3 ml/kg (0.2 ml/kg/min). Inhibition was dose dependent and was decreased when the dose of perflubron emulsion was reduced to 1.0 or 0.3 ml/kg. Infusion of saline or "vehicle" emulsions had little or no effect on stimulated ex-vivo pig platelet aggregation. Fluosol, infusion was associated with inconsistent inhibit...Continue Reading

References

Apr 1, 1989·Metabolism: Clinical and Experimental·M Aviram, R J Deckelbaum
Jul 1, 1983·Medical Hypotheses·R E Cowan, R P Thompson

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Citations

Dec 10, 2015·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·William A CroninRichard T Mahon
Mar 1, 1995·Perfusion·A Marchbank
Jan 1, 1995·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·R K Spence
Aug 1, 1996·Journal of Neurosurgery·D E SakasN T Zervas

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