Effect of a high protein intake on acid-base balance in adult rats

Calcified Tissue International
G Trilok, H H Draper

Abstract

Adult rats are able to maintain Ca balance under protein loads that produce Ca loss in adult humans. This species difference was investigated by determining the relationship between protein intake, endogenous acid production (EAP), net acid excretion (NAE), and urinary Ca in adult rats for comparison with a similar study on adult humans. Diets containing 10, 30, and 50% casein were fed in conjunction with proportionate increments in the sulfur amino acid (SAA) methionine (0.6, 1.8, and 3.0%). Urine volume, Ca, sulfate, organic anions, TA (titratable acidity as acid phosphates), and ammonium increased progressively with increases in protein intake, and pH decreased. When protein intake was increased at a constant level of SAA, no increase in urinary Ca, sulfate, and TA or decrease in pH was observed. Both SAA and non-SAA enhanced ammonium excretion but only non-SAA enhanced organic anion excretion, an indicator of incomplete oxidation of organic acids. SAA were responsible for 89 and 91% of the increase in EAP and Ca excretion, respectively, caused by increasing protein intake from 10-30% of the diet. In a comparison experiment, human adults on a high protein intake exhibited a much smaller increase in acid excretion as ammonium...Continue Reading

References

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Citations

Sep 26, 2003·The Proceedings of the Nutrition Society·Tim Arnett
May 6, 2008·Journal of Midwifery & Women's Health·Jenifer O Fahey
Aug 22, 2008·The Journal of Nutrition·Ryan N Dilger, David H Baker
May 27, 2021·Journal of Extracellular Vesicles·Uta ErdbrüggerElena S Martens-Uzunova

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