Abstract
This study assessed the efficacy of long-term l-arginine (l-arg) therapy in preventing or delaying type 2 diabetes mellitus. A mono-centre, randomized, double-blind, parallel-group, placebo-controlled, phase III trial (l-arg trial) was conducted on 144 individuals affected by impaired glucose tolerance (IGT) and metabolic syndrome (MS). l-Arg/placebo was administered (6.4 g/day) on a background structured lifestyle intervention for 18 months plus a 12-month extended follow-up period after study drug termination. Fasting glucose levels and glucose tolerance after oral glucose tolerance test were evaluated throughout the study. After 18 months, l-arg as compared with placebo did not reduce the cumulative incidence of diabetes [21.4 and 20.8%, respectively, hazard ratio (HR), 1.04; 95% confidence interval (CI), 0.58-1.86] while the cumulative probability to become normal glucose tolerant (NGT) increased (42.4 and 22.1%, respectively, HR, 2.60; 95% CI, 1.51-4.46, p < 0.001). The higher cumulative probability to become of NGT was maintained during the extended period in subjects previously treated with l-arg (HR, 3.21; 95% CI, 1.87-5.51; p < 0.001). At the end of the extended period, the cumulative incidence of diabetes in subjects ...Continue Reading
References
Apr 15, 1996·The Journal of Clinical Investigation·P ClarksonJ E Deanfield
Jun 15, 1996·Circulation·T S RectorS H Kubo
Apr 1, 1997·Diabetes Care·X R PanB V Howard
Aug 1, 1997·European Journal of Clinical Investigation·T C WascherH Toplak
Nov 21, 1998·Free Radical Biology & Medicine·I K Mohan, U N Das
May 20, 1999·Diabetes Care·M CoutinhoS Yusuf
May 3, 2001·The New England Journal of Medicine·J TuomilehtoUNKNOWN Finnish Diabetes Prevention Study Group
May 12, 2001·Diabetes Care·P M PiattiK G Alberti
Feb 8, 2002·The New England Journal of Medicine·William C KnowlerUNKNOWN Diabetes Prevention Program Research Group
Jun 28, 2002·Diabetes·Christine C JensenUNKNOWN American Diabetes Association GENNID Study Group
Jul 2, 2002·Lancet·Anna NorhammarKlas Malmberg
Oct 8, 2003·Circulation·PierMarco PiattiAntonio Colombo
Jul 6, 2005·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·José D Méndez, Roberto De Haro Hernández
Jul 28, 2005·Diabetes·Abbas E KitabchiUNKNOWN Diabetes Prevention Program Research Group
Sep 6, 2005·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Wei-Hsian YinShing-Jong Lin
Jan 5, 2006·JAMA : the Journal of the American Medical Association·Steven P SchulmanGary Gerstenblith
Jun 15, 2006·American Journal of Physiology. Endocrinology and Metabolism·Pietro LucottiPierMarco Piatti
Sep 19, 2006·The New England Journal of Medicine·UNKNOWN DREAM Trial InvestigatorsRury R Holman
Nov 14, 2006·Lancet·Jaana LindströmUNKNOWN Finnish Diabetes Prevention Study Group
Mar 1, 2007·Diabetes Care·Miriam CnopSteven E Kahn
May 3, 2007·Diabetes·Clinton C MasonWilliam C Knowler
May 22, 2007·The Journal of Nutrition·Rainer H Böger
Aug 25, 2007·The Journal of Physiology·Ana VasilijevicBato Korac
May 27, 2008·Lancet·Guangwei LiPeter H Bennett
Sep 6, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Francis KimMichael W Schwartz
Nov 26, 2008·Amino Acids·Guoyao WuYulong Yin
Dec 6, 2008·The American Journal of Clinical Nutrition·Yongyi BaiRutai Hui
Jul 14, 2009·Metabolism: Clinical and Experimental·Pietro LucottiPiermarco Piatti
Nov 3, 2009·Lancet·William C KnowlerDavid M Nathan
Dec 17, 2009·Diabetes Care·Anthony J HanleyUNKNOWN Diabetes Reduction Assessment With Ramipril and Rosiglitazone Medication (DREAM) Investigators
Mar 5, 2010·The American Journal of Clinical Nutrition·Stéphane DoutreleauBernard Geny
Mar 17, 2010·The New England Journal of Medicine·Rury R HolmanRobert M Califf
May 4, 2010·Amino Acids·Jason R McKnightGuoyao Wu
Jul 14, 2010·The Journal of Nutritional Biochemistry·Bie TanGuoyao Wu
Mar 25, 2011·The New England Journal of Medicine·Ralph A DeFronzoUNKNOWN ACT NOW Study
Citations
Jan 30, 2013·Lasers in Medical Science·N Kazemi KhooZ Zamani
Jun 18, 2014·Acta Diabetologica·PierMarco PiattiLucilla D Monti
Nov 16, 2013·European Journal of Applied Physiology·Mauricio KrauseGiuseppe De Vito
Sep 20, 2015·Metabolism: Clinical and Experimental·Lucilla D MontiPiermarco Piatti
Sep 18, 2012·Journal of Diabetes·Eduardo Cabrera-RodeEmma Domínguez
Apr 5, 2013·BioFactors·Zhaolai DaiGuoyao Wu
Oct 15, 2014·Diabetes, Obesity & Metabolism·M A BethelM J Theodorakis
Dec 3, 2014·Journal of Hepatology·Ludger Scheja, Johannes Kluwe
Mar 18, 2015·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Roksana B ZakGlenn A Wright
Jun 19, 2016·European Journal of Nutrition·Thiago R AraujoRosane A Ribeiro
Nov 7, 2016·European Journal of Nutrition·Daniel MenzelHorst Robenek
Apr 7, 2017·Journal of Dietary Supplements·Eduardo Cabrera-RodeOscar Díaz-Díaz
Aug 28, 2018·Diabetes, Obesity & Metabolism·Edward YuMiguel A Martínez-González
Nov 1, 2018·Diabetologia·Mariëtte R BoonWouter D van Marken Lichtenbelt
Apr 28, 2018·Amino Acids·Kelly J PeytonWilliam Durante
Jul 13, 2019·Food & Function·Chengjun HuXiangfeng Kong
Oct 19, 2017·Frontiers in Neurology·Sang-Hwa LeeJong-Hee Sohn
Dec 24, 2018·Nutrients·Josianne Rodrigues-KrauseAna Paula Trussardi Fayh
Dec 10, 2016·The Journal of Nutrition·Catherine J McNealGuoyao Wu
Oct 21, 2017·European Journal of Nutrition·Lucilla D MontiPier Marco Piatti
Dec 7, 2017·Seminars in Immunopathology·Gerald Grandl, Christian Wolfrum
Oct 12, 2018·Nutrients·Cheng-Shyuan RauChing-Hua Hsieh
Apr 25, 2019·Scientific Reports·Morgane RoblesPascale Chavatte-Palmer
Jan 12, 2021·Archives of Physiology and Biochemistry·Elham KarimiGholamreza Askari
Aug 30, 2020·Clinical Nutrition ESPEN·Arman ArabMaryam Nasirian
Mar 21, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Elena GalluccioLucilla D Monti
Aug 14, 2020·Journal of Agricultural and Food Chemistry·Xiaoxia HuangRuili Yang
Sep 22, 2021·Endocrine·Lucilla D MontiPiermarco Piatti
Oct 25, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Anne M FitzpatrickJocelyn R Grunwell