Effect of a low-impact exercise program on bone mineral density in Crohn's disease: a randomized controlled trial

Gastroenterology
R J RobinsonJ F Mayberry

Abstract

Physical exercise increases bone mineral density (BMD) in healthy young adults and slows the rate of bone loss in later life. The aim of this randomized controlled trial was to investigate the effect of exercise on BMD in patients with Crohn's disease. A total of 117 patients with Crohn's disease were randomized to a control group or a low-impact exercise program of increasing intensity. BMD (g/cm2) was measured at baseline and 12 months at the hip and spine (L2-L4) by dual energy x-ray absorptiometry. Nonsignificant gains in BMD occurred at the hip and spine in the exercise group compared with controls (P > 0.05). In fully compliant patients, BMD increased by 3.54% (7.95%) at the femoral neck, 2.97% (7.7%) at the spine, 4.1% (10.26%) at Ward's triangle, and 7.77% (8.2%) at the greater trochanter. Compared with controls, gain in BMD at the greater trochanter was statistically significant (difference in means, 4.67; 95% confidence interval, 0.86-8.48; P = 0.02). Increases in BMD were significantly related to the number of exercise sessions completed (femoral neck; r = 0.28; 95% confidence interval, 0.10-0.45; P = 0.04). Progressive low-impact exercise is a potentially effective method of increasing BMD in Crohn's disease. If sus...Continue Reading

References

Sep 1, 1992·Digestive Diseases and Sciences·F PigotB Amor
Apr 1, 1987·Gut·J E CompstonJ Rhodes
Sep 1, 1986·The Journal of Clinical Investigation·N A PocockS Eberl
Nov 1, 1995·Annals of the Rheumatic Diseases·E J Bassey
Oct 1, 1995·Journal of Epidemiology and Community Health·M HillsdonJ Morris
Feb 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C N BernsteinF Shanahan
Mar 1, 1994·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·E J Bassey, S J Ramsdale
Jan 1, 1993·Medicine and Science in Sports and Exercise·B E AinsworthR S Paffenbarger
Jan 1, 1993·Calcified Tissue International·H M Frost
Jan 1, 1996·Bone·A H MyersJ A Langlois
Nov 15, 1996·Journal of the American College of Cardiology·R W BraithM L Pollock
Feb 22, 1997·BMJ : British Medical Journal·M E McMurdoC R Paterson

❮ Previous
Next ❯

Citations

Sep 12, 2000·Current Gastroenterology Reports·I Lopez, A L Buchman
Sep 19, 2001·Current Gastroenterology Reports·J C Southerland, J F Valentine
Jul 13, 2004·Current Gastroenterology Reports·Cynthia Hamilton, Douglas L Seidner
Sep 12, 2000·Current Gastroenterology Reports·D G Kelly
May 11, 2002·Current Treatment Options in Gastroenterology·Alan L. Buchman
Feb 11, 2005·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Jesse S SiffledeenGordon Greenberg
Apr 23, 2002·Alimentary Pharmacology & Therapeutics·V AbitbolUNKNOWN Groupe D'etudes Thérapeutiques des Affections Inflammatoires Digestives (GETAID)
Oct 7, 2006·Current Opinion in Gastroenterology·S B Hanauer
Jun 20, 2002·European Journal of Gastroenterology & Hepatology·Nicole BregenzerTilo Andus
Aug 24, 1999·Inflammatory Bowel Diseases·R M Issenman
Aug 24, 1999·Inflammatory Bowel Diseases·J D Adachi, A Rostom
Aug 24, 1999·Inflammatory Bowel Diseases·A L Buchman
Nov 25, 2005·Inflammatory Bowel Diseases·Naomi LeeDennis R Taaffe
Jun 23, 2011·Journal of Pediatric Gastroenterology and Nutrition·Helen PappaCatherine Gordon
Nov 18, 2011·Southern Medical Journal·Donald Martin
Nov 8, 2013·The Pan African Medical Journal·Aida Ben Slama TrabelsiAli Jmaa
Nov 26, 2010·World Journal of Gastroenterology : WJG·Pal MihellerPeter-Laszlo Lakatos
May 31, 2014·BioMed Research International·Jan BilskiTomasz Brzozowski
May 15, 2003·Current Treatment Options in Gastroenterology·Adrian A. Van Bodegraven, A. Salvador Peña
Jul 27, 2001·Current Treatment Options in Gastroenterology·Ad A. van BodegravenStephan G. M. Meuwissen
Dec 22, 2010·Journal of Crohn's & Colitis·Carlos Ayán Pérez
Apr 28, 2011·Alimentary Pharmacology & Therapeutics·S G VeerappanB M Ryan
May 14, 2011·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·K GerasimidisC A Edwards
Aug 23, 2000·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·A L Buchman, A Moukarzel
Feb 28, 2015·Inflammatory Bowel Diseases·Patricia D JonesMillie D Long
Jun 4, 2016·Pharmacological Reports : PR·Jan BilskiTomasz Brzozowski
Oct 17, 2016·Gastroenterology·Adam S CheifetzPeter R Gibson
Aug 13, 2010·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Maria R Mascarenhas, Meena Thayu
Feb 21, 2002·Inflammatory Bowel Diseases·Aida HabtezionA Hillary Steinhart
May 11, 2002·The American Journal of Gastroenterology·Maria Cino, Gordon R Greenberg
Sep 14, 2017·Journal of Pediatric Endocrinology & Metabolism : JPEM·Ángel Matute-LlorenteJosé A Casajús
Jun 10, 2010·Journal of Pediatric Gastroenterology and Nutrition·Susanne SchmidtRobert Saalman
Mar 23, 1999·The American Journal of Gastroenterology·C P LoudonC N Bernstein
Mar 10, 2000·The American Journal of Gastroenterology·R Dresner-PollakD Rachmilewitz
Sep 1, 2005·The American Journal of Gastroenterology·Michael BernsteinGordon R Greenberg
Nov 1, 2005·The Physician and Sportsmedicine·Victor K Ng, Wanda M Millard
Jun 13, 2012·Journal of Pediatric Gastroenterology and Nutrition·Susanne SchmidtRobert Saalman
Dec 12, 2019·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A A van Bodegraven, N Bravenboer
Jun 26, 2020·United European Gastroenterology Journal·Wolfgang Alexander SeegerAxel Dignass

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