Effect of a monoclonal anti-lyt-1.1 on the functional activity of precursor, effector, and regulatory cells specific for murine alloantigens

Transplantation
J ShawV Paetkau

Abstract

A monoclonal anti-Lyt-1.1 serum has been characterized in terms of its effect on various cell populations involved in cell-mediated immune responses. The monoclonal serum was compared to a conventionally prepared anti-Lyt-1.1 serum. Cytotoxic T cell precursors and effectors were found to be Lyt-1.1+. Helper T cells which participate in the induction of a cytotoxic response were also Lyt-1.1+ as were suppressor T cells which inhibit cytotoxic responses. The T cell that is required for the production of a nonspecific stimulatory factor, costimulator, and that has been shown to bear the same Ly markers as does the helper T cell, bears Lyt-1.1. Finally, the effector cell which mediates delayed-type hypersensitivity reactions to alloantigens has been shown to be Lyt-1.1+. In all of these cases treatment with the monoclonal anti-Lyt-1.1 and complement had the same effect as did treatment with a conventional anti-Lyt-1.1 and complement. The distribution of Lyt-1.1 on various cell types as determined using the monoclonal anti-Lyt-1.1 is in complete agreement with the Lyt-1.1 distribution obtained with conventional anti-Lyt-1.1 sera, and is quite different from the reactivity of an anti-Thy-1 serum as determined by strain distribution. ...Continue Reading

Citations

Jan 1, 1981·Immunogenetics·M S Sandrin, I F McKenzie
Aug 1, 1982·Biulleten' eksperimental'noĭ biologii i meditsiny·V F SemenkovM N Korotkova
Apr 27, 1984·Journal of Immunological Methods·J Barrington-Leigh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antibody Specificity

Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.

Related Papers

The Journal of Immunology : Official Journal of the American Association of Immunologists
P M HogarthI F McKenzie
The Journal of Immunology : Official Journal of the American Association of Immunologists
C Henry, E L Chan
© 2021 Meta ULC. All rights reserved