PMID: 7545516May 1, 1995Paper

Effect of a new non-steroidal anti-inflammatory drug, nitroflurbiprofen, on the expression of inducible nitric oxide synthase in rat neutrophils

British Journal of Pharmacology
S MariottoG Benoni

Abstract

The effects of a non-steroidal anti-inflammatory drug, flurbiprofen, and its nitro-derivative, nitroflurbiprofen, on inducible nitric oxide synthase in rat neutrophils were examined. Nitroflurbiprofen was shown to inhibit nitric oxide synthase induction caused by lipopolysaccharide administration, while flurbiprofen had no effect on nitric oxide synthase induction. This inhibitory action may be ascribed to nitric oxide released from nitroflurbiprofen.

References

Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·D S Bredt, S H Snyder
Jul 1, 1984·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·B Bartholomew
Oct 1, 1982·Analytical Biochemistry·L C GreenS R Tannenbaum
Nov 1, 1993·British Journal of Pharmacology·N K Boughton-SmithS Moncada
Jun 15, 1994·Biochemical and Biophysical Research Communications·S K ParkS Murphy
Mar 1, 1993·British Journal of Pharmacology·J AssreuyS Moncada

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Citations

Apr 15, 2004·Journal of Neuroimmunology·Roberto FurlanGianvito Martino
Dec 8, 2000·Thrombosis Research·S Sethi, M Dikshit
May 24, 2000·Brain Research Bulletin·M Colasanti, T Persichini
Aug 6, 2000·British Journal of Pharmacology·O A al-SwayehP K Moore
Mar 9, 2005·Proceedings of the National Academy of Sciences of the United States of America·Carmela De SantoVincenzo Bronte
Sep 21, 2011·The Journal of Experimental Medicine·Barbara MolonAntonella Viola
Jun 15, 2006·Antioxidants & Redox Signaling·Tiziana PersichiniMarco Colasanti
Mar 11, 2005·Expert Opinion on Emerging Drugs·Lukas Radbruch, Frank Elsner
Apr 25, 2008·Cancer Letters·Luigi DolcettiVincenzo Bronte
Feb 1, 2005·European Journal of Pharmacology·Paula ZacharowskiJane Mitchell
Mar 4, 2005·Arthritis Research & Therapy·Franco CapsoniMario Carrabba
Jan 1, 1996·Life Sciences·N C StratmanV H Sethy

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