PMID: 11917956Mar 29, 2002Paper

Effect of a nitric oxide donor on microcirculation of acutely denervated skeletal muscle during reperfusion

Journal of Reconstructive Microsurgery
Chen-Hsi ChouJ R Urbaniak

Abstract

The authors have shown that exogenous nitric oxide (NO) protects innervated skeletal muscle against reperfusion injury. This study further evaluated the effects of exogenous NO donor on denervated skeletal muscle. Forty-eight denervated rat cremaster muscles underwent 3 hr of ischemia, followed by 90 min of reperfusion, and received systemic infusion of 100 nmol/min s-nitroso-n-acetylcysteine (SNAC) or an equal amount of phosphate-buffered saline (PBS). Results showed that the average diameter in 10 to 20 microm arterioles was between 107 percent and 123 percent of baseline in the SNAC group, and between 55 percent and 84 percent in the PBS group during 90 min of reperfusion. These values in 21 to 40 microm and 41 to 70 microm arteries were between 100 percent and 110 percent in the SNAC group, and between 70 percent and 90 percent in the PBS group from 20 to 90 min of reperfusion. Compared to the PBS group, the SNAC group had a statistically significantly greater vessel diameter in both 10 to 20 microm (p<0.001) and 21 to 40 microm arterioles (p<0.01) during 90 min of reperfusion, and in 41 to 70 microm arteries (p<0.02) from 20 to 90 min of reperfusion. The overall blood flow of the muscle in the SNAC group increased from 37 ...Continue Reading

Citations

Jun 1, 2005·The Journal of Hand Surgery·Jong Woong ParkLong-En Chen
Jun 18, 2005·The Journal of Surgical Research·Achal KhannaRobert A Fitridge
Dec 21, 2010·Transplantation Proceedings·R Scherer de FragaM R Álvares-da-Silva
Sep 8, 2004·Nitric Oxide : Biology and Chemistry·Charan GowdaJames R Urbaniak
Jul 14, 2004·The Journal of Hand Surgery·Wen-Ning QiJames R Urbaniak
Sep 21, 2004·Microsurgery·Maria Siemionow, Emrah Arslan
Apr 7, 2007·Annals of Plastic Surgery·Holger EngelMarkus V Küntscher
Nov 13, 2007·Microsurgery·Honggang WangXiaolin Liu
Dec 19, 2019·Annals of Plastic Surgery·Emre GazyakanHolger Engel
Dec 31, 2002·Journal of Applied Physiology·Li ZhangJames R Urbaniak
Sep 8, 2020·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Emre GazyakanHolger Engel

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