PMID: 8586488Jul 1, 1995Paper

Effect of a novel anti-rheumatic drug, TA-383, on type II collagen-induced arthritis

International Journal of Immunopharmacology
M UenoM Takeshita

Abstract

The effects of Ta-383 (0.016, 0.08, 0.4, 2 and 10 mg/kg) and anti-rheumatic drugs (lobenzarit 10 and 50 mg/kg, dexamethasone 0.25 mg/kg) were evaluated on type II collagen-induced arthritis in DBA/1J mice. The arthritis score was markedly suppressed in the groups treated with dexamethasone and TA-383. Serum anti-type II collagen IgG was significantly suppressed in the groups treated with dexamethasone and 0.4 mg/kg TA-383. Histopathological evaluation of the knee joints revealed suppression of the inflammatory changes in the groups treated with dexamethasone and TA-383. These findings suggest that the histopathological examination of the joints of the animal model is useful for the evaluation of anti-rheumatic drugs, and that TA-383 has suppressive effects on type II collagen-induced arthritis, an animal model for human rheumatoid arthritis.

References

Nov 1, 1987·Japanese Journal of Pharmacology·K KomoriyaT Naruchi
Jul 1, 1982·The Journal of Investigative Dermatology·J M StuartA H Kang

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Citations

Jan 1, 2008·Acta Crystallographica. Section E, Structure Reports Online·Reza KiaHadi Kargar
Jan 1, 2008·Acta Crystallographica. Section E, Structure Reports Online·Reza KiaHadi Kargar
Jan 1, 2009·Acta Crystallographica. Section E, Structure Reports Online·Reza KiaHadi Kargar
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Jan 1, 2009·Acta Crystallographica. Section E, Structure Reports Online·Reza KiaHadi Kargar
Jan 1, 2009·Acta Crystallographica. Section E, Structure Reports Online·Reza KiaHadi Kargar
Jan 1, 2009·Acta Crystallographica. Section E, Structure Reports Online·Reza KiaHadi Kargar
Jan 1, 2009·Acta Crystallographica. Section E, Structure Reports Online·Reza KiaHadi Kargar
Aug 13, 2014·BioMed Research International·Nagaraja HaleagraharaAmmu Radhakrishnan
Feb 1, 2006·Expert Opinion on Therapeutic Patents·Jinxia DengNouri Neamati
Jan 24, 2014·Acta Crystallographica. Section E, Structure Reports Online·Shaaban K MohamedMustafa R Albayati
Dec 14, 2004·Arthritis and Rheumatism·Gaby PalmerNathalie Busso
Aug 14, 2008·Analytical Chemistry·Cornelius T MarthaHubertus Irth
May 14, 2014·The Journal of Organic Chemistry·Guido V JanssenRomano V A Orru
Jun 29, 2013·The Journal of Organic Chemistry·Wendy A LoughlinMaria J Petersson
Feb 16, 2007·The Journal of Organic Chemistry·Shikha GandhiVinod K Singh
Apr 23, 2005·The Journal of Organic Chemistry·Robin S BonRomano V A Orru
Jul 14, 2007·The Journal of Organic Chemistry·Niels EldersRomano V A Orru
Nov 25, 2005·Journal of the American Chemical Society·Veejendra K Yadav, Vardhineedi Sriramurthy
May 25, 2002·The Journal of Organic Chemistry·Nicola A BolandMartin P Smyth

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