Effect of a novel free radical scavenger, edaravone, on puromycin aminonucleoside induced nephrosis in rats

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Tomonosuke SomeyaYuichiro Yamashiro


Recent studies indicate that excessive production of oxidants plays a role in the pathogenesis of glomerular injury leading to proteinuria in patients with minimal-change nephrotic syndrome (MCNS). The novel free radical scavenger, edaravone (EDA), which was recently developed in Japan, is currently used in patients with stroke. We studied whether this new agent would be beneficial in patients with MCNS by its antioxidant activity and examined its effect on proteinuria in nephrosis induced by puromycin-aminonucleoside (PAN) in rats. Nineteen Wistar-Kyoto rats injected with PAN were assigned to four groups: group 1, without EDA (n=4); group 2, concomitant EDA injection from 1 day prior to PAN administration (n=5); group 3, concomitant EDA injection from 1 day after PAN administration (n=5); group 4, concomitant EDA injection from 3 days after PAN administration (n=5). Daily urinary excretions of protein and 8-hydroxy-2'-deoxyguanosine (8-OHdG), a new sensitive marker of oxidative DNA damage in vivo, were measured in each group from the 1st to the 30th day after PAN injection. In group 1 proteinuria developed from the 5th day and reached the peak level on the 9th day. In groups 2, 3, and 4 proteinuria did not appear until the 6th...Continue Reading


Jan 21, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Anna IharadaToshimasa Nishiyama
Jul 25, 2012·Free Radical Biology & Medicine·Qiaojing YanJian Yao
Mar 1, 2012·Journal of the American Society of Hypertension : JASH·Li-Juan MinMasatsugu Horiuchi
Jun 30, 2015·Laboratory Investigation; a Journal of Technical Methods and Pathology·Izabella Z A PawluczykPeter S Topham
Nov 5, 2016·Clinical and Experimental Nephrology·Keisuke SugimotoTsukasa Takemura
Sep 13, 2012·Experimental and Therapeutic Medicine·Kiyoshi KikuchiKo-Ichi Kawahara


Mar 1, 1992·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J R Diamond
Jan 1, 1991·Free Radical Biology & Medicine·M K Shigenaga, B N Ames
Nov 1, 1991·Kidney International·R T FiserB Shirkey
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·C G FragaB N Ames
Apr 1, 1988·Stroke; a Journal of Cerebral Circulation·K AbeK Kogure
Feb 1, 1986·Kidney International·J R DiamondM J Karnovsky
May 1, 1996·Free Radical Research·U MinhazH Nakazawa
Jan 1, 1997·Free Radical Biology & Medicine·S TúriJ Nagy
Oct 23, 1997·The Journal of Biological Chemistry·C J RaatsJ H Berden
Jan 5, 1999·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·J FydrykH Bukowska
Jan 12, 2000·Archives of Disease in Childhood·S KinraB C Kabi
Dec 31, 2002·Journal of the American Society of Nephrology : JASN·Hiroshi KawachiFujio Shimizu
Mar 22, 2003·The Journal of Pharmacology and Experimental Therapeutics·Minoru SatohHirofumi Makino
Sep 5, 2003·The Journal of Pharmacology and Experimental Therapeutics·Hiroshi KonoYoshiro Matsumoto
Sep 24, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Young Ki LeeHirashi Kawachi

Related Concepts

Pathogenic Aspects
Nephrotic Syndrome
Renal Glomerular Disease
Free Radicals
MCI 186

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