Effect of a novel penetration enhancer on the ungual permeation of two antifungal agents

The Journal of Pharmacy and Pharmacology
M J TraynorM B Brown

Abstract

The aim of this study was to demonstrate the effect of a novel permeation enhancer system using two existing marketed nail lacquers and the delivery of terbinafine through human nail samples in vitro. Initially a modified Franz cell was used, where sections of human nail serve as the barrier through which drug penetrates into an agar-filled chamber infected with dermatophytes. A second study was performed using a novel infected nail model where dermatophytes are incubated with and grow into human nail and ATP levels are used as biological marker for antimicrobial activity. The novel permeation enhancing system increased the permeation of both existing drugs formulated in nail lacquers and terbinafine through human nail sections mounted in a modified Franz cell. Furthermore the ATP assay confirmed that the system also enhanced the permeation of terbinafine through infected cadaver nail resulting in a decrease in ATP levels equivalent to those of uninfected negative control samples. This study has clearly demonstrated that the use of a novel permeation enhancing system, which fundamentally alters the chemical structure of the nail, not only enhances the efficacy of the existing topical formulations but also enables the delivery a...Continue Reading

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Citations

Oct 13, 2012·Drug Development and Industrial Pharmacy·Anroop B NairBandar E Al-Dhubiab
Apr 23, 2013·Drug Development and Industrial Pharmacy·Farhaan HafeezHoward Maibach
Aug 10, 2012·Drug Development and Industrial Pharmacy·Xiaoying HuiHoward I Maibach
Nov 1, 2017·Antimicrobial Agents and Chemotherapy·Natsuki Kubota-IshidaHoward I Maibach
Sep 4, 2018·Expert Opinion on Drug Delivery·Marc BrownSean Robert Wevrett
Apr 26, 2017·Antimicrobial Agents and Chemotherapy·Luisa ChristensenMarc Brown
Jun 1, 2012·European Journal of Clinical Pharmacology·José A Morales-MolinaM Angustias Molina-Arrebola
Jul 14, 2012·European Journal of Clinical Pharmacology·José A Morales-MolinaM José Gíménez-López
Apr 29, 2015·International Journal of Cosmetic Science·P ThataiB Sapra
May 21, 2020·International Journal of Molecular Sciences·Anton ValkovMarina Nisnevitch
Jun 28, 2014·AAPS PharmSciTech·Biji B PalliyilDavid B Lebo

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