PMID: 7540663Jul 1, 1995Paper

Effect of a novel prolyl endopeptidase inhibitor, JTP-4819, on prolyl endopeptidase activity and substance P- and arginine-vasopressin-like immunoreactivity in the brains of aged rats

Journal of Neurochemistry
K ToideT Kato

Abstract

The effects of a novel prolyl endopeptidase (PEP) inhibitor, (S)-2-[[(S)-2-(hydroxyacetyl)-1-pyrrolidinyl]carbonyl]-N-(phenylmethyl) - 1-pyrrolidinecarboxamide (JTP-4819), on the PEP activity in the brain and on the contents of substance P (SP)- and arginine-vasopressin (AVP)-like immunoreactivity (LI) in the cerebral cortex and hippocampus of young and aged rats were investigated using enzyme immunoassay. JTP-4819 exhibited a concentration-dependent in vitro inhibitory action on PEP activity in the brains of both young and aged rats, with IC50 values of approximately 0.7 and 0.8 nM, respectively. A single dose of JTP-4819 (3 mg/kg, p.o.) increased the SPLI content in the cerebral cortex but not the hippocampus of aged rats (23-24 months old). In addition, repeated administration of JTP-4819 (1 mg/kg, p.o., for 21 days) increased the SPLI content in the cerebral cortex and restored the SPLI content in the hippocampus, which had decreased with aging. In contrast, single (1 mg/kg, p.o.) and repeated (1 mg/kg, p.o., for 21 days) administration of JTP-4819 only tended to increase the AVPLI content of the hippocampus and cerebral cortex in aged rats, respectively. These results indicate that JTP-4819 increases the cerebral and hippo...Continue Reading

Citations

Jan 25, 2007·Basic & Clinical Pharmacology & Toxicology·Aaro J JalkanenPekka T Männistö
Aug 19, 2009·Chembiochem : a European Journal of Chemical Biology·Eduard SabidóErnest Giralt
Aug 19, 2009·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Timo T MyöhänenPekka T Männistö
Jun 17, 2010·The AAPS Journal·Anna Mari LoneAlan Saghatelian
Jun 29, 2011·Basic & Clinical Pharmacology & Toxicology·Aaro J JalkanenMarkus M Forsberg
Jul 13, 2012·Journal of Human Genetics·Jin LiXia Li
Feb 27, 2004·The Journal of Comparative Neurology·Gaelle BellemèreSylvie Jégou
Oct 7, 2003·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Naiara AgirregoitiaLuis Casis
Apr 17, 2010·Chembiochem : a European Journal of Chemical Biology·Nessim KichikErnest Giralt
Aug 21, 2007·Archives of Pharmacal Research·Seung-Ho LeeKyung-Sik Song
Jul 3, 2003·Médecine sciences : M/S·Gaëlle BellemèreHubert Vaudry
Sep 13, 2013·Future Medicinal Chemistry·Abraham LópezErnest Giralt
May 8, 2019·Zygote : the Biology of Gametes and Early Embryos·Massimo VendittiSergio Minucci
Apr 17, 2019·Molecular Reproduction and Development·Ping XuChunping Zhang
Feb 1, 1996·Naunyn-Schmiedeberg's Archives of Pharmacology·K ToideT Kato
Jul 12, 2008·Histochemistry and Cell Biology·Timo T MyöhänenPekka T Männistö
May 5, 2011·Expert Opinion on Therapeutic Patents·Abraham LópezErnest Giralt
Aug 21, 2013·Nature Protocols·Yun-Gon KimAlan Saghatelian
Jan 12, 2010·Journal of Medicinal Chemistry·Janice LawandiNicolas Moitessier
Jun 27, 1997·Biochemical and Biophysical Research Communications·M ShinodaS Kohsaka
Nov 17, 2009·Biochemistry·Whitney M NolteAlan Saghatelian
Oct 13, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Inger BrandtAnne-Marie Lambeir
Jan 2, 2007·Neuropeptides·J A García-HorsmanJ I Venäläinen
Jul 27, 2011·Biochemistry·Arthur D Tinoco, Alan Saghatelian
Nov 26, 2008·Pharmacology & Therapeutics·Uros V DjekicNathaniel M Weathington
May 30, 2009·Bioorganic & Medicinal Chemistry Letters·Eduard SabidóErnest Giralt
Sep 28, 2010·Biochimica Et Biophysica Acta·Zoltán SzeltnerLászló Polgár

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Aging

Here is the latest research on intrinsic and extrinsic factors, as well as pathways and mechanisms that underlie aging in the central nervous system.